ZFIN Feature: ti282a

ZFIN ID: ZDB-ALT-980203-1091

ZFIN ID: ZDB-ALT-980203-1091

Genomic Feature:	ti282a
Synonyms:	AI82A (1)
Affected Genomic Regions:	fgf8a
Type:	Point Mutation (1)
Protocol:	adult males treated with ENU
Lab Of Origin:	Nüsslein-Volhard Lab
Location:	Chr 13: 28498881 (GRCz11) (1) Details
Sequence:
Current Sources:	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

MUTATION DETAILS

DNA/cDNA Change:	G>A in Donor Splice Site of Intron 2 (1)
Transcript Consequence:	Splice Site , Exon Loss of Exon 2, Premature Stop (1)
Protein Consequence:	Polypeptide Truncation (1)

FLANKING SEQUENCE (GENOMIC)

CGCATTTAACTCAAAAACTTCATAATAATTTTAATTATTTATTTATTTTAATTATTTATTTAAGTTGTTGGTATGTGGGTGACATGTGATAACAATTCACATGTTGTTTATGTACTTGCATAAAAGGTAAAAAGTTTAAAGCCCTGCCAGAAAGCCTTTGGTTCCTTCCAGAAGAATTGAAGTGCACATGTTTTTATCATTCTGCTAGATTTTAAGCTTACATAAATCCTAAAGAGTAGTCCCTTCGGATTTCACATATTTATGCCCGTATGTATGCATATCTCTTTGTGCATATGCGCATGTGTGTTTACTCCTGAACTTTTCCTTTTTGAAATGTAATTCAATTTTCCACAAAGTCACAACGTCTAATAAAATCTTCTTTTCTTTTTATAGCCAAGCTTATAGTAGAGACGGACACATTTGGGAGTCGAGTTCGAATTAAAGGAGCTGAAACAGGCTTTTACATCTGTATGAACAGGAGGGGGAAACTGATTGGCAAG

G/A

TATGTGAAAAAGTCATCACTTTTGTGACTTACTAAAACTGTTCAGTTGACATCCCAAACACAGCATATGCTTCAGTCATACCGCAAGATTTTGAATGCATGAGAAGAATCCCACCTAGAAAGGGAAAAAAAAGATCAATTAATTCAGAAACGTCACTCATAAGCTCATGTAGTAATTTCAGCATTCATTAGTTTGTAGATGAGACATTTCTGATTTAATTAAGATGATTATTCAAAACATCCATCAAATTTATATGTTTTATTTGTTAGTTGGCACTAGACACCTTCTGGTTGCAGCAGGTAAAATCGAGTTTGAAGAATGGGATCTTTCTTCCTTTTTTTAGCTGGCTACTCTTGTTCCAATGTGGATTTGTGCCTTCTCCTTGCTGTGAATGGTAATAAAGTGGGATGGAGGTTCGGCCCCCACCTCCCAGCACCCTACCAGGTGGACCATCTGCTTGGCACCCCTGATCTTATGCTATCTGACATATTGGCCGCCCA

(1)

Comment	Citation
acerebellar ti282a mutants have a G>A mutation in the 5' splice donor ...	Reifers et al., 1998

OTHER ti282a PAGES No links to external sites

GENOTYPES

Zygosity	Genotype (Background)	Affected Genomic Regions	Parental Zygosity
Homozygous	fgf8a^{ti282a/ti282a}	fgf8a	Unknown
	fgf8a^{ti282a/ti282a}	fgf8a	♀+/- ♂+/-
Heterozygous	fgf8a^ti282a/+	fgf8a	♀+/- ♂+/+
	fgf8a^ti282a/+	fgf8a	♀+/- ♂+/-
	fgf8a^ti282a/+	fgf8a	Unknown
	fgf8a^ti282a/+ (AB)	fgf8a	Unknown
Complex	fgf24^{t22030/t22030}; fgf8a^{ti282a/ti282a}	fgf8a, fgf24
	fgf3^t24149/+; fgf8a^ti282a/+	fgf3, fgf8a
	fgf3^t24149/+; fgf8a^{ti282a/ti282a}	fgf3, fgf8a
	fgf3^{t24149/t24149}; fgf8a^ti282a/+	fgf3, fgf8a
	fgf3^{t24149/t24149}; fgf8a^{ti282a/ti282a}	fgf3, fgf8a
	fgf8a^ti282a/+ ; smad5^b1100/+	fgf8a, smad5
	fgf8a^{ti282a/ti282a} ; fgf3^t24149/+	fgf3, fgf8a
	fgf8a^{ti282a/ti282a} ; smad5^b1100/b1100	fgf8a, smad5
	fgf8a^{ti282a/ti282a}; pax2a^tu29a/tu29a	fgf8a, pax2a
	fgf8a^{ti282a/ti282a}; shha^{tbx392/tbx392}	fgf8a, shha
	fgf8a^{ti282a/ti282a}; tdgf1^tz257/tz257	fgf8a, tdgf1
	fgf8a^{ti282a/ti282a}; tdgf1^tz257/tz257	fgf8a, tdgf1
	fgf8a^{ti282a/ti282a}; wls^c186/c186	fgf8a, wls
	fgf8a^{ti282a/ti282a}; wnt11r^fh224/fh224	fgf8a, wnt11
	smad5^b1100/+ ; fgf8a^{ti282a/ti282a}	fgf8a, smad5
	smad5^b1100/b1100 ; fgf8a^ti282a/+	fgf8a, smad5
	fgf8a^ti282a/+; rerea^tb210/tb210	fgf8a, rerea
	fgf8a^{ti282a/ti282a}; aus^t294	aus, fgf8a
	fgf8a^{ti282a/ti282a}; rerea^tb210/tb210	fgf8a, rerea
	fgf8a^{ti282a/ti282a}; f2Tg	fgf8a
	fgf8a^{ti282a/ti282a}; ne1939Tg	fgf8a
	fgf8a^{ti282a/ti282a}; pt6Tg	fgf8a
	fgf8a^{ti282a/ti282a}; sqet11Et	fgf8a
	fgf8a^{ti282a/ti282a}; zf15Tg	fgf8a
	fgf8a^{ti282a/ti282a}; el72Tg; pt6Tg	fgf8a

CITATIONS (132)