Genomic Feature

m1061

ID
ZDB-ALT-150325-1
Name
m1061
Synonyms
None
Affected Genomic Region
Construct
None
Type
Allele with one point mutation (1)
Protocol
sperm treated with ENU
Lab of Origin
Driever Lab
Current Source
Other Pages
Note
Koch et al (2014): C-to-T mutation at bp 82 of the ORF of cnot8 results in the formation of a premature stop codon.The premature stop codon causes the formation of a truncated Cnot8 peptide which lacks most of its RNAse domain and should lack its poly deadenylation function.
Genome Browser
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Variants
Variant Type
Point Mutation
Variant Location
Chr 21: 36452569 (GRCz11) (1) Details
Nucleotide change
G/A
Variant Notes
Koch et al (2014): C-to-T mutation at bp 82 of the ORF of cnot8 results in the  ...
Effect on DNA/cDNA, transcript, protein (from publications)
DNA/cDNA Change
C>T at position 82 (1)
Transcript Consequence
Premature Stop (1)
Protein Consequence
Polypeptide Truncation: Arg>Stop (1)
Sequences
Flanking Sequence
ATATATATATATATATATATATATATATATATATATATATATATATATACATATATATGTATGCATGTATGTATGCATGTATGTATGCATGTATGCATGTATGTATGCATGTATGTATGCATGTATGTATGCATGTATGTATGCATGTATGTATGTATGTATGCATGTATGTATGCATGTATGTATGTATGTATGTATTTTGTTCCCCAGCAAGCTAAATATTATTGTTTTCACTTTGAAGATTTTGCTTGTTTTAAGAAAACAAACTTAATGTTTTCCTGAAATCAAAACATTCAATGTTTTTTACTTGTCTAGAAAATGCTTCAAGATTAAAGTATTTTTTGTGAAATTCAGACTAGAAATAACACAAAAGTAAGAAATGCTATTTGGTTTGAATTTGGTAATTGTCAGAAAAGCCTAATTTAGTAGAATCCTGATGGTCCATCAATGCAAACACAAACACACCATGGCAATGTAGTTGTAGTTCTGAATGATCTGTC
G/A TATCTTCCTCATCTCCTCCTCCACATTGCTGGCCCAGACCTCGCAGATAATTTGACTGGTATCTGCAAGTGCGGCTGGCATGATGATGATGAAGGCAGAGGAACCAATTCGAGAATCCCAGAGGTCCTGCACAGCCAAAAAGAAACTCTGTCAGGAAGAGCAAATTGAGTTAATGAGCTTTAAAATCAATTCTCTTGGAAATTACTCCTATTTTAAACAAAGTATAAAAATCTTTTAAATTACATGGCGATTATTGAAGGATAGAGATCAATGTTTAAAAAGACTACCTAGGAGATTTAAATAATGAGTTTATTAGTAGAATACTCCATGTATCTGCATTAATAACACGACGGGTGAAATTAAATCAACAACTGGAAAGTGTTTGTTTAATAACAGCAAATCTTCCAATAAAAACTTGAATTAATTAAATGTGAAACGCTAATAAACGTAAAGATTCTTTAATATCAAAGCATTTTAGGCGAATATTCACATATCTACCA
Additional Sequence
None
Fish
Supplemental Information
Genotyping protocol
None
Citations