ZFIN ID: ZDB-EXP-161221-5
Experiment Conditions Description: chemical treatment by environment: EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, chemical treatment by environment: dactolisib
chemical treatment by environment: EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
Synonyms: ATP:protein phosphotransferase (MAPKK-activated) inhibitor, ATP:protein phosphotransferase (MAPKK-activated) inhibitors, c-Jun N-terminal kinase inhibitor, c-Jun N-terminal kinase inhibitors, Dp38 inhibitor, Dp38 inhibitors, EC 2.7.11.24 (mitogen-activated protein kinase) inhibitors, EC 2.7.11.24 inhibitor, EC 2.7.11.24 inhibitors, ERK inhibitor, ERK inhibitors, ERK1 inhibitor, ERK1 inhibitors, ERK2 inhibitor, ERK2 inhibitors, extracellular signal-regulated kinase inhibitor, extracellular signal-regulated kinase inhibitors, JNK inhibitor, JNK inhibitors, JNK3alpha1 inhibitor, JNK3alpha1 inhibitors, LeMPK3 inhibitor, LeMPK3 inhibitors, MAP kinase inhibitor, MAP kinase inhibitors, MAP-2 kinase inhibitor, MAP-2 kinase inhibitors, MAPK inhibitor, MAPK inhibitors, MBP kinase I inhibitor, MBP kinase I inhibitors, MBP kinase II inhibitor, MBP kinase II inhibitors, MEK inhibitor, MEK inhibitors, microtubule-associated protein 2 kinase inhibitor, microtubule-associated protein 2 kinase inhibitors, microtubule-associated protein kinase inhibitor, microtubule-associated protein kinase inhibitors, mitogen-activated protein kinase (EC 2.7.11.24) inhibitor, mitogen-activated protein kinase (EC 2.7.11.24) inhibitors, mitogen-activated protein kinase inhibitor, mitogen-activated protein kinase inhibitors, myelin basic protein kinase inhibitor, myelin basic protein kinase inhibitors, p38-2 inhibitor, p38-2 inhibitors, p38delta inhibitor, p38delta inhibitors, p42 mitogen-activated protein kinase inhibitor, p42 mitogen-activated protein kinase inhibitors, p42(mapk) inhibitor, p42(mapk) inhibitors, p44mpk inhibitor, p44mpk inhibitors, PMK-1 inhibitor, PMK-1 inhibitors, PMK-2 inhibitor, PMK-2 inhibitors, PMK-3 inhibitor, PMK-3 inhibitors, pp42 inhibitor, pp42 inhibitors, pp44(mapk) inhibitor, pp44(mapk) inhibitors, SAPK inhibitor, SAPK inhibitors, STK26 inhibitor, STK26 inhibitors, stress-activated protein kinase inhibitor, stress-activated protein kinase inhibitors
Definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24).
Ontology: ChEBI [CHEBI:79091]  ( EBI )
chemical treatment by environment: dactolisib
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: dactolisib
Synonyms: 2-methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile, BEZ 235, BEZ-235, BEZ235, NVP BEZ235, NVP-BEZ 235, NVP-BEZ235, NVPBEZ235
Definition: An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.
Ontology: ChEBI [CHEBI:71952]  ( EBI )
Publication: Fernandez Del Ama et al., 2016