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ZIRC
ZFIN ID: ZDB-EXP-161027-6
Experiment Conditions Description: chemical treatment: methionine sulfoximine, chemical treatment: 5-fluorouracil
chemical treatment: methionine sulfoximine
Name: chemical treatment
Synonyms:
Definition: Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000111]
Name: methionine sulfoximine
Synonyms: 2-amino-4-(S-methylsulfonimidoyl)butanoic acid, 2-amino-4-(S-methylsulphonimidoyl)butyric acid, Methionine sulfoximine
Definition: A non-proteinogenic alpha-amino acid that is the sulfoximine derivative of methionine .
Ontology: Chebi [CHEBI:47833]
chemical treatment: 5-fluorouracil
Name: chemical treatment
Synonyms:
Definition: Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000111]
Name: 5-fluorouracil
Synonyms: 5-Fluoracil, 5-fluoropyrimidine-2,4(1H,3H)-dione, 5-Fluoropyrimidine-2,4-dione, 5-fluorouracil, 5-FU, fluorouracil, fluorouracilo, fluorouracilum
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Ontology: Chebi [CHEBI:46345]
Publication: Cox et al., 2016