Gene

hpn

ID
ZDB-GENE-141212-373
Name
hepsin
Symbol
hpn Nomenclature History
Previous Names
  • si:ch73-124g13.3 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable scavenger receptor activity; serine-type endopeptidase activity; and serine-type exopeptidase activity. Acts upstream of or within blood coagulation, fibrin clot formation and regulation of serine-type endopeptidase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human HPN (hepsin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Khandekar et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hpn Human Ortholog
No data available
Associated With hpn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018114 Serine proteases, trypsin family, histidine active site
Active_site IPR033116 Serine proteases, trypsin family, serine active site
Domain IPR001190 SRCR domain
Domain IPR001254 Serine proteases, trypsin domain
Domain IPR015352 Hepsin, SRCR domain
Family IPR001314 Peptidase S1A, chymotrypsin family
Family IPR038957 Hepsin
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR036772 SRCR-like domain superfamily
Homologous_superfamily IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
Domain Details Per Protein
Protein Length Hepsin Hepsin, SRCR domain Peptidase S1A, chymotrypsin family Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold Serine proteases, trypsin domain Serine proteases, trypsin family, histidine active site Serine proteases, trypsin family, serine active site SRCR domain SRCR-like domain superfamily
UniProtKB:A8DZG9 425
UniProtKB:A5D6S2 423
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations