Gene

aff2

ID
ZDB-GENE-110411-190
Name
AF4/FMR2 family, member 2
Symbol
aff2 Nomenclature History
Previous Names
  • si:ch211-76h4.1
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable G-quadruplex RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleus. Predicted to be active in nuclear speck. Is expressed in intermediate cell mass of mesoderm. Human ortholog(s) of this gene implicated in X-linked intellectual developmental disorder 109. Orthologous to human AFF2 (AF4/FMR2 family member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Armant et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With aff2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
X-linked intellectual developmental disorder 109 Alliance Intellectual developmental disorder, X-linked 109 309548
Associated With aff2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR043639 AF4 interaction motif
Domain IPR043640 AF4/FMR2, C-terminal homology domain
Family IPR007797 AF4/FMR2 family
Domain Details Per Protein
Protein Length AF4/FMR2, C-terminal homology domain AF4/FMR2 family AF4 interaction motif
UniProtKB:A0A0R4IGG2 45
UniProtKB:E7F2E1 1269
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations