Gene

dock8

ID
ZDB-GENE-060503-743
Name
dedicator of cytokinesis 8
Symbol
dock8 Nomenclature History
Previous Names
  • im:7154406 (1)
  • si:dkey-91m11.1
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 2 and hyper IgE recurrent infection syndrome 2. Is expressed in forebrain; midbrain; and ventricular zone. Orthologous to human DOCK8 (dedicator of cytokinesis 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dock8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hyper IgE recurrent infection syndrome 2 Alliance Hyper-IgE recurrent infection syndrome, autosomal recessive 243700
Associated With dock8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR010703 Dedicator of cytokinesis, C-terminal
Domain IPR021816 Dedicator of cytokinesis C/D, N-terminal
Domain IPR027007 DHR-1 domain
Domain IPR027357 DHR-2 domain
Domain IPR037808 Dedicator of cytokinesis C, C2 domain
Family IPR026791 Dedicator of cytokinesis
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR043161 Dedicator of cytokinesis, C-terminal, lobe A
Homologous_superfamily IPR043162 Dedicator of cytokinesis, C-terminal, lobe C
Domain Details Per Protein
Protein Length Armadillo-type fold C2 domain superfamily Dedicator of cytokinesis Dedicator of cytokinesis C, C2 domain Dedicator of cytokinesis C/D, N-terminal Dedicator of cytokinesis, C-terminal Dedicator of cytokinesis, C-terminal, lobe A Dedicator of cytokinesis, C-terminal, lobe C DHR-1 domain DHR-2 domain
UniProtKB:F1RB11 189
UniProtKB:Q6PHG5 513
UniProtKB:F1QJ79 2090
UniProtKB:B0V2T6 2034
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations