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Gene

nrg1

ID
ZDB-GENE-050302-113
Name
neuregulin 1
Symbol
nrg1 Nomenclature History
Previous Names
  • wu:fm70e01
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable chemorepellent activity and protein tyrosine kinase activator activity. Acts upstream of or within several processes, including enteric nervous system development; fin regeneration; and neurogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Is expressed in gut; heart; nervous system; and somite. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 12 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nrg1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
schizophrenia 6 Alliance {?Schizophrenia, susceptibility to} 603013
Associated With nrg1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR002154 Neuregulin, C-terminal
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Family IPR040180 Neuregulin
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length EGF-like domain Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Neuregulin Neuregulin, C-terminal
UniProtKB:B9VQK7 725
UniProtKB:B3DK99 599
UniProtKB:A0A1B4Z255 604
UniProtKB:B9VQK8 722
UniProtKB:Q20CG4 599
UniProtKB:A0A0R4IFE6 687
UniProtKB:A0A0R4IBM0 730
UniProtKB:A0A0R4IPH3 722
UniProtKB:B9VQK9 730
UniProtKB:A0A0R4IDP7 725
UniProtKB:B9VQL0 687
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-nrg1 Rabbit
1
Ab2-nrg1 Rabbit
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations