Gene

agk

ID
ZDB-GENE-030131-6202
Name
acylglycerol kinase
Symbol
agk Nomenclature History
Previous Names
  • fi38e09
  • mulk
  • wu:fi38e09
  • zgc:55462 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable acylglycerol kinase activity; ceramide kinase activity; and diacylglycerol kinase activity. Predicted to be involved in ceramide biosynthetic process; phosphorylation; and protein insertion into mitochondrial inner membrane. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be integral component of mitochondrial inner membrane. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex. Predicted to be active in membrane and mitochondrion. Human ortholog(s) of this gene implicated in Sengers syndrome and cataract 38. Orthologous to human AGK (acylglycerol kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With agk Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cataract 38 Alliance Cataract 38, autosomal recessive 614691
Sengers syndrome Alliance Sengers syndrome 212350
Associated With agk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001206 Diacylglycerol kinase, catalytic domain
Homologous_superfamily IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
Homologous_superfamily IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
Domain Details Per Protein
Protein Length Diacylglycerol kinase, catalytic domain Inorganic polyphosphate/ATP-NAD kinase, N-terminal NAD kinase/diacylglycerol kinase-like domain superfamily
UniProtKB:Q7ZW00 422
UniProtKB:A0A2R8RHM6 422
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations