Gene

lrpap1

ID
ZDB-GENE-030131-5871
Name
low density lipoprotein receptor-related protein associated protein 1
Symbol
lrpap1 Nomenclature History
Previous Names
  • wu:fi20f07
  • wu:fi22c06
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable lipase binding activity; lipoprotein particle receptor binding activity; and receptor antagonist activity. Predicted to be involved in negative regulation of receptor internalization and negative regulation of very-low-density lipoprotein particle clearance. Predicted to be located in endoplasmic reticulum. Predicted to be active in several cellular components, including cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; and rough endoplasmic reticulum lumen. Is expressed in neural tube; otic placode; and pronephric duct. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lrpap1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
myopia Alliance Myopia 23, autosomal recessive 615431
Associated With lrpap1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009066 Alpha-2-macroglobulin receptor-associated protein, domain 1
Domain IPR010483 Alpha-2-macroglobulin RAP, C-terminal
Domain IPR037999 Alpha-2-macroglobulin RAP, domain 3
Domain IPR038001 Alpha-2-macroglobulin RAP, domain 2
Family IPR038003 Alpha-2-macroglobulin receptor-associated protein
Homologous_superfamily IPR036744 RAP domain superfamily
Domain Details Per Protein
Protein Length Alpha-2-macroglobulin RAP, C-terminal Alpha-2-macroglobulin RAP, domain 2 Alpha-2-macroglobulin RAP, domain 3 Alpha-2-macroglobulin receptor-associated protein Alpha-2-macroglobulin receptor-associated protein, domain 1 RAP domain superfamily
UniProtKB:A2BGU5 345
UniProtKB:A0A2R8QMD9 345
UniProtKB:Q7ZW96 331
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations