ZFIN ID: ZDB-TALEN-180531-2
TALEN Name: TALEN5-rb1
Target: rb1 (1)
Source:
Target Sequence 1:
5' - CCAGTCCACTAACT - 3'
   
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Target Sequence 2:
5' - CTCCCATATTCTCCAT - 3'
   
Select Sequence Analysis Tool

  (Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.)
TARGET LOCATIONS
No data available
CONSTRUCTS WITH SEQUENCES FROM TALEN5-rb1 No data available
GENOMIC FEATURES CREATED WITH TALEN5-rb1
Genomic Feature Affected Genomic Regions    
sm11 rb1    
GENE EXPRESSION
Gene expression in Wild Types + TALEN5-rb1 No data available
PHENOTYPE
Phenotype resulting from TALEN5-rb1
No data available

Phenotype of all Fish created by or utilizing TALEN5-rb1
Phenotype Fish Conditions Figures
cysteine-type endopeptidase activity involved in apoptotic process increased process quality, abnormal rb1sm11/sm11 control Fig. 4 with image from Zhang et al., 2017
whole organism rb1 expression absent, abnormal rb1sm11/sm11 control Fig. 1 from Zhang et al., 2017
thymus rag1 expression decreased amount, abnormal rb1sm11/sm11 control Fig. 2 with image from Zhang et al., 2017
whole organism casp3a expression increased amount, abnormal rb1sm11/sm11 control Fig. 5 with image from Zhang et al., 2017
thymus lymphocyte ikzf1 expression decreased amount, abnormal rb1sm11/sm11 control Fig. 2 with image from Zhang et al., 2017
whole organism e2f1 expression increased amount, abnormal rb1sm11/sm11 control Fig. 5 with image from Zhang et al., 2017
thymus anatomical region e2f1 expression increased amount, abnormal rb1sm11/sm11 control Fig. 5 with image from Zhang et al., 2017
thymus anatomical region rag2 expression decreased amount, abnormal rb1sm11/sm11 control Fig. 2 with image from Zhang et al., 2017
whole organism rag2 expression decreased amount, abnormal rb1sm11/sm11 control Fig. 5 with image from Zhang et al., 2017
whole organism linc-tcrb expression decreased amount, abnormal rb1sm11/sm11 control Fig. 5 with image from Zhang et al., 2017
thymus anatomical region casp3a expression increased amount, abnormal rb1sm11/sm11 control Fig. 4 with image from Zhang et al., 2017
thymus T cell lck expression decreased amount, abnormal rb1sm11/sm11 control Fig. 2 with image from Zhang et al., 2017
thymus anatomical region cd4-1 expression decreased amount, abnormal rb1sm11/sm11 control Fig. 2 with image from Zhang et al., 2017
whole organism cd247 expression decreased amount, abnormal rb1sm11/sm11 control Fig. 5 with image from Zhang et al., 2017
whole organism trac expression decreased amount, abnormal rb1sm11/sm11 control Fig. 5 with image from Zhang et al., 2017
whole organism decreased life span, abnormal rb1sm11/sm11 control Fig. 1 from Zhang et al., 2017
thymus T cell decreased amount, ameliorated rb1sm11/sm11 ; zf411Tg chemical treatment by environment: Z-Val-Ala-Asp(OMe)-CH2F Fig. 4 with image from Zhang et al., 2017
T cell cell maturation decreased occurrence, abnormal rb1sm11/sm11 ; zf411Tg control Fig. 2 with image from Zhang et al., 2017
thymus T cell decreased amount, abnormal rb1sm11/sm11 ; zf411Tg control Fig. 2 with imageFig. 4 with imageFig. 5 with image from Zhang et al., 2017
T cell apoptotic process increased occurrence, abnormal rb1sm11/sm11 ; zf411Tg control Fig. 3 with imageFig. 5 with image from Zhang et al., 2017
whole organism cd247 expression amount, ameliorated rb1sm11/sm11 + MO1-e2f1 control Fig. 5 with image from Zhang et al., 2017
whole organism rag2 expression amount, ameliorated rb1sm11/sm11 + MO1-e2f1 control Fig. 5 with image from Zhang et al., 2017
whole organism casp3a expression amount, ameliorated rb1sm11/sm11 + MO1-e2f1 control Fig. 5 with image from Zhang et al., 2017
whole organism e2f1 expression amount, ameliorated rb1sm11/sm11 + MO1-e2f1 control Fig. 5 with image from Zhang et al., 2017
whole organism linc-tcrb expression amount, ameliorated rb1sm11/sm11 + MO1-e2f1 control Fig. 5 with image from Zhang et al., 2017
whole organism trac expression amount, ameliorated rb1sm11/sm11 + MO1-e2f1 control Fig. 5 with image from Zhang et al., 2017
T cell apoptotic process occurrence, ameliorated rb1sm11/sm11 ; zf411Tg + MO1-e2f1 control Fig. 5 with image from Zhang et al., 2017
thymus T cell decreased amount, ameliorated rb1sm11/sm11 ; zf411Tg + MO1-e2f1 control Fig. 5 with image from Zhang et al., 2017
thymus T cell decreased amount, abnormal rb1sm11/sm11 ; zf411Tg ; tp53zdf1/zdf1 control Fig. 4 with image from Zhang et al., 2017
OTHER TALEN5-rb1 TALEN PAGESNo links to external sites
CITATIONS (1)