ZFIN ID: ZDB-TALEN-160129-1
TALEN Name: TALEN1-gba
Target: gba (1)
Source:
Target Sequence 1:
5' - TCTGTACCCTGATTACTT - 3'
   
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Target Sequence 2:
5' - TGGACTCCACCCAGCGCAT - 3'
   
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  (Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.)
TARGET LOCATION
No data available
CONSTRUCTS WITH SEQUENCES FROM TALEN1-gba No data available
GENOMIC FEATURES CREATED WITH TALEN1-gba
Genomic Feature Affected Genomic Regions    
sh391 gba    
GENE EXPRESSION
Gene expression in Wild Types + TALEN1-gba No data available
PHENOTYPE
Phenotype resulting from TALEN1-gba
No data available

Phenotype of all Fish created by or utilizing TALEN1-gba
Phenotype Fish Conditions Figures
glucosylceramidase activity decreased process quality, abnormal gbash391/sh391(TL) standard conditions Fig. 1 from Keatinge et al., 2015
brain macrophage morphology, abnormal gbash391/sh391(TL) standard conditions Fig. 5 from Keatinge et al., 2015
brain macrophage increased amount, abnormal gbash391/sh391(TL) standard conditions Fig. 5 from Keatinge et al., 2015
thymus macrophage morphology, abnormal gbash391/sh391(TL) standard conditions Fig. 5 from Keatinge et al., 2015
brain cytochrome-c oxidase activity decreased process quality, abnormal gbash391/sh391(TL) standard conditions Fig. 8 from Keatinge et al., 2015
brain autophagosome increased amount, abnormal gbash391/sh391(TL) standard conditions Fig. 8 from Keatinge et al., 2015
swimming decreased process quality, abnormal gbash391/sh391(TL) standard conditions Fig. 4 from Keatinge et al., 2015
liver macrophage increased amount, abnormal gbash391/sh391(TL) standard conditions Fig. 5 from Keatinge et al., 2015
CNS neuron (sensu Vertebrata) inclusion body increased amount, abnormal gbash391/sh391(TL) standard conditions Fig. 7 from Keatinge et al., 2015
liver macrophage morphology, abnormal gbash391/sh391(TL) standard conditions Fig. 5 from Keatinge et al., 2015
caudal periventricular hypothalamus dopaminergic neuron decreased amount, abnormal gbash391/sh391(TL) standard conditions Fig. 7 from Keatinge et al., 2015
brain mitochondrion decreased functionality, abnormal gbash391/sh391(TL) standard conditions Fig. 8 from Keatinge et al., 2015
tectal ventricle macrophage increased size, abnormal gbash391/sh391(TL) standard conditions Fig. 5 from Keatinge et al., 2015
brain hexosaminidase activity increased process quality, abnormal gbash391/sh391(TL) standard conditions Fig. 3 from Keatinge et al., 2015
sphingolipid metabolic process disrupted, abnormal gbash391/sh391(TL) standard conditions Fig. 2 from Keatinge et al., 2015
macrophage increased accumulation tectal ventricle, abnormal gbash391/sh391(TL) standard conditions Fig. 5 from Keatinge et al., 2015
brain chitinase activity increased process quality, abnormal gbash391/sh391(TL) standard conditions Fig. 3 from Keatinge et al., 2015
brain ubiquinol-cytochrome-c reductase activity decreased process quality, abnormal gbash391/sh391(TL) standard conditions Fig. 8 from Keatinge et al., 2015
spinal cord curved, abnormal gbash391/sh391(TL) standard conditions Fig. 3 from Keatinge et al., 2015
whole organism decreased life span, abnormal gbash391/sh391(TL) standard conditions text only from Keatinge et al., 2015
caudal tuberculum dopaminergic neuron decreased amount, abnormal gbash391/sh391(TL) standard conditions Fig. 7 from Keatinge et al., 2015
whole organism dead, abnormal gbash391/sh391(TL) standard conditions text only from Keatinge et al., 2015
brain glial cell projection retracted, abnormal gbash391/sh391(TL) standard conditions Fig. 5 from Keatinge et al., 2015
brain microglial cell circular, abnormal gbash391/sh391(TL) standard conditions Fig. 5 from Keatinge et al., 2015
microglial cell increased accumulation brain, abnormal gbash391/sh391(TL) standard conditions Fig. 5 from Keatinge et al., 2015
thymus macrophage increased amount, abnormal gbash391/sh391(TL) standard conditions Fig. 5 from Keatinge et al., 2015
brain sncb expression decreased amount, abnormal gbash391/sh391(TL) standard conditions Fig. 7 from Keatinge et al., 2015
microglial cell spherical, abnormal gbash391/sh391 ; sh425Tg(TL) standard conditions Fig. 6 from Keatinge et al., 2015
brain mir155 expression increased amount, abnormal gbash391/sh391 ; sh425Tg(TL) standard conditions Fig. 6 from Keatinge et al., 2015
microglial cell activation increased occurrence, abnormal gbash391/sh391 ; sh425Tg(TL) standard conditions Fig. 6 from Keatinge et al., 2015
microglial cell vacuole increased amount, abnormal gbash391/sh391 ; sh425Tg(TL) standard conditions Fig. 6 from Keatinge et al., 2015
whole organism mir155 expression increased amount, abnormal gbash391/sh391 ; sh425Tg(TL) standard conditions Fig. 6 from Keatinge et al., 2015
OTHER TALEN1-gba TALEN PAGESNo links to external sites
CITATIONS (1)