PUBLICATION
A second CYP26 P450 in humans and zebrafish: CYP26B1
- Authors
- Nelson, D.R.
- ID
- ZDB-PUB-991112-4
- Date
- 1999
- Source
- Archives of biochemistry and biophysics 371(2): 345-347 (Journal)
- Registered Authors
- Keywords
- cytochrome P450;retinoic acid; CYP26; human; zebrafish
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Chromosome Mapping
- Cytochrome P-450 Enzyme System/genetics*
- Expressed Sequence Tags
- Humans
- Isoenzymes/genetics
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Zebrafish
- PubMed
- 10545224 Full text @ Arch. Biochem. Biophys.
Citation
Nelson, D.R. (1999) A second CYP26 P450 in humans and zebrafish: CYP26B1. Archives of biochemistry and biophysics. 371(2):345-347.
Abstract
A new P450 gene has been found in humans. It has 44% sequence identity to CYP26A1 from human and mouse, which places it in a new subfamily, CYP26B. There is only one human EST from a retinal library (AA012833) that matches the coding region. No homologous ESTs are found in mouse. A zebrafish EST AI721901 shows 68% identity to the human protein. This zebrafish EST is only 41% identical to the zebrafish CYP26A1 protein sequence, so it represents the homolog of the human CYP26B1 sequence. It is not known if this gene product will act on all-trans-retinoic acid like the CYP26A1 protein or if it might hydroxylate the 9-cis- or 13-cis-retinoic acid isoforms not recognized by CYP26A1. The importance of the CYP26A1 P450 in mouse and zebrafish development flags the CYP26B1 gene as a potential developmental gene.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping