PUBLICATION

Maturation of neuromuscular transmission during early development in zebrafish

Authors
Nguyen, P.V., Aniksztejn, L., Catarsi, S., and Drapeau, P.
ID
ZDB-PUB-990628-18
Date
1999
Source
Journal of neurophysiology   81(6): 2852-2861 (Journal)
Registered Authors
Aniksztejn, Laurent, Drapeau, Pierre, Nguyen, Peter V.
Keywords
none
MeSH Terms
  • Animals
  • Cholinesterase Inhibitors/pharmacology
  • Electric Stimulation
  • Embryo, Nonmammalian
  • In Vitro Techniques
  • Kinetics
  • Larva
  • Motor Endplate/growth & development
  • Motor Endplate/physiology
  • Muscle Fibers, Skeletal/physiology
  • Neuromuscular Junction/growth & development
  • Neuromuscular Junction/physiology*
  • Patch-Clamp Techniques
  • Physostigmine/pharmacology
  • Receptors, Cholinergic/metabolism
  • Synaptic Transmission/physiology*
  • Zebrafish
PubMed
10368402 Full text @ J. Neurophysiol.
Abstract
Maturation of neuromuscular transmission during early development in zebrafish. We have examined the rapid development of synaptic transmission at the neuromuscular junction (NMJ) in zebrafish embryos and larvae by patch-clamp recording of spontaneous miniature endplate currents (mEPCs) and single acetylcholine receptor (AChR) channels. Embryonic (24-36 h) mEPCs recorded in vivo were small in amplitude (<50 pA). The rate of mEPCs increased in larvae (3.5-fold increase measured by 6 days), and these mEPCs were mostly of larger amplitude (10-fold on average) with (
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping