PUBLICATION
The genetics of midline and cardiac laterality defects
- Authors
- Yost, H.J.
- ID
- ZDB-PUB-990108-3
- Date
- 1998
- Source
- Current opinion in cardiology 13: 185-189 (Review)
- Registered Authors
- Yost, H. Joseph
- Keywords
- none
- MeSH Terms
-
- Animals
- Female
- Gene Expression Regulation, Developmental/physiology
- Heart Defects, Congenital/embryology
- Heart Defects, Congenital/genetics*
- Humans
- Infant, Newborn
- Pregnancy
- Risk Factors
- Zebrafish
- PubMed
- 9649941
Citation
Yost, H.J. (1998) The genetics of midline and cardiac laterality defects. Current opinion in cardiology. 13:185-189.
Abstract
Left-right asymmetric looping of the cardiac tube during embryogenesis places the segments of the cardiac tube that give rise to the left and right chambers into their appropriate spatial orientation. Cardiac looping is required for subsequent formation of septa, valves, and outflow tract. Defects in embryonic left-right axis formation represent a significant portion of congenital heart malformations. Recent discoveries make it apparent that the orientation of cardiac tube looping is dependent on a cascade of genes in noncardiac embryonic cells, including lateral cells and midline cells, before neural tube closure. These observations suggest a linkage between complex cardiac defects and subtle midline defects in early embryos.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping