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ZFIN ID: ZDB-PUB-981020-5
Transient expression of a novel Six3-related zebrafish gene during gastrulation and eye formation
Seo, H.C., Drivenes, O., Ellingsen, S., and Fjose, A.
Date: 1998
Source: Gene 216: 39-46 (Journal)
Registered Authors: Drivenes, Oyvind, Ellingsen, Ståle, Fjose, Anders, Seo, Hee-Chan
Keywords: Danio rerio; homeodomain; in situ hybridization; RT-PCR
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • DNA/chemistry
  • DNA/genetics
  • DNA/isolation & purification
  • Eye/chemistry
  • Eye/embryology*
  • Eye/metabolism
  • Eye Proteins
  • Gastrula/chemistry
  • Gastrula/metabolism*
  • Gene Expression/genetics
  • Gene Expression Regulation, Developmental
  • Genes/genetics*
  • Homeodomain Proteins/genetics*
  • Homeodomain Proteins/metabolism
  • Molecular Sequence Data
  • Nerve Tissue Proteins/genetics
  • Sequence Homology, Amino Acid
  • Time Factors
  • Tissue Distribution
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Zebrafish Proteins*
PubMed: 9714724 Full text @ Gene
Both the Drosophila homeobox gene sine oculis and its murine homologue Six3 have regulatory functions in eye development. In zebrafish, in addition to two previously reported homologues of murine Six3, we have identified a related gene (six7). Although the deduced Six7 protein shares less than 68% sequence identity with the other known zebrafish Six3-like proteins, the embryonic expression patterns have highly conserved features. The six7 transcripts are first detected in involuting axial mesendoderm and, subsequently, in the overlying neurectoderm from which the forebrain and optic primordia develop. Similar to the two other zebrafish Six3 homologues, the expression boundaries of six7 correspond quite closely with the edges of the optic vesicles. Hence, the partially overlapping expression domains of these three six genes probably contribute to anteroposterior specification and in defining the eye primordia.