ZFIN ID: ZDB-PUB-970327-4
Dynamo, a new zebrafish DVR member of the TGF-b superfamily is expressed in the posterior neural tube and is up-regulated by Sonic hedgehog
Bruneau, S. and Rosa, F.M.
Date: 1997
Source: Mechanisms of Development   61(1-2): 199-212 (Journal)
Registered Authors: Bruneau, Sylvia, Rosa, Frederic
Keywords: posterior neural tube; transforming growth factor-b; Sonic hedgehog; zebrafish; axial mutants
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Biomarkers
  • DNA, Complementary/genetics
  • Gastrula
  • Gene Expression Regulation, Developmental
  • Genes
  • Growth Differentiation Factor 6
  • Hedgehog Proteins
  • In Situ Hybridization
  • Molecular Sequence Data
  • Multigene Family
  • Nerve Tissue Proteins/genetics*
  • Nervous System/embryology*
  • Notochord/physiology
  • Proteins/genetics*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Trans-Activators*
  • Up-Regulation
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish Proteins*
PubMed: 9076689 Full text @ Mech. Dev.
ABSTRACT
Dynamo, a new zebrafish DVR detected from late gastrula on in the posterior neural plate, becomes restricted to the ventral region of the trunk neural tube, with the exclusion of floor plate and adjacent cells. Analysis of dynamo expression in zebrafish axial mutants indicated that dynamo expression in the ventral region of the central nervous system (CNS) is induced by axial mesoderm and maintained by notochord, but is independent of a differentiated floor plate. Ectopic Sonic hedgehog (shh) expression can up-regulate dynamo expression in the posterior neural tube providing evidence that cells of the posterior neural tube are competent to respond to shh signalling and that the close relationship between DVR members and hedgehog-related genes might also apply to vertebrate CNS development.
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