PUBLICATION

Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration

Authors
Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K.
ID
ZDB-PUB-220907-2
Date
2022
Source
Frontiers in immunology   13: 981000 (Journal)
Registered Authors
Hui, Subhra Prakash, Kikuchi, Kazu, Sheng, Delicia
Keywords
Tregs, blastema, fin regeneration, growth factors, zebrafish
MeSH Terms
  • Animals
  • Cell Proliferation
  • Signal Transduction/genetics
  • T-Lymphocytes, Regulatory*/metabolism
  • Zebrafish*/genetics
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed
36059461 Full text @ Front Immunol
Abstract
The role of T cells in appendage regeneration remains unclear. In this study, we revealed an important role for regulatory T cells (Tregs), a subset of T cells that regulate tolerance and tissue repair, in the epimorphic regeneration of zebrafish caudal fin tissue. Upon amputation, fin tissue-resident Tregs infiltrate into the blastema, a population of progenitor cells that produce new fin tissues. Conditional genetic ablation of Tregs attenuates blastemal cell proliferation during fin regeneration. Blastema-infiltrating Tregs upregulate the expression of igf2a and igf2b, and pharmacological activation of IGF signaling restores blastemal proliferation in Treg-ablated zebrafish. These findings further extend our understandings of Treg function in tissue regeneration and repair.
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