PUBLICATION
Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish
- Authors
- Wee, C.L., Song, E., Nikitchenko, M., Herrera, K.J., Wong, S., Engert, F., Kunes, S.
- ID
- ZDB-PUB-220514-3
- Date
- 2022
- Source
- Nature communications 13: 2573 (Journal)
- Registered Authors
- Engert, Florian
- Keywords
- none
- MeSH Terms
-
- Animals
- Appetite
- Avoidance Learning*
- Behavior, Animal
- Larva/physiology
- Social Behavior
- Social Isolation
- Zebrafish*/metabolism
- PubMed
- 35545618 Full text @ Nat. Commun.
Citation
Wee, C.L., Song, E., Nikitchenko, M., Herrera, K.J., Wong, S., Engert, F., Kunes, S. (2022) Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish. Nature communications. 13:2573.
Abstract
Animal brains have evolved to encode social stimuli and transform these representations into advantageous behavioral responses. The commonalities and differences of these representations across species are not well-understood. Here, we show that social isolation activates an oxytocinergic (OXT), nociceptive circuit in the larval zebrafish hypothalamus and that chemical cues released from conspecific animals are potent modulators of this circuit's activity. We delineate an olfactory to subpallial pathway that transmits chemical social cues to OXT circuitry, where they are transformed into diverse outputs simultaneously regulating avoidance and feeding behaviors. Our data allow us to propose a model through which social stimuli are integrated within a fundamental neural circuit to mediate diverse adaptive behaviours.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping