PUBLICATION
The interaction of Notch and Wnt signaling pathways in vertebrate regeneration
- Authors
- Gao, J., Fan, L., Zhao, L., Su, Y.
- ID
- ZDB-PUB-220203-15
- Date
- 2021
- Source
- Cell regeneration (London, England) 10: 11 (Review)
- Registered Authors
- Gao, Junying, Su, Ying, Zhao, Long
- Keywords
- Crosstalk, Notch signaling, Regeneration, Wnt signaling
- MeSH Terms
- none
- PubMed
- 33791915 Full text @ Cell Regen (Lond)
Citation
Gao, J., Fan, L., Zhao, L., Su, Y. (2021) The interaction of Notch and Wnt signaling pathways in vertebrate regeneration. Cell regeneration (London, England). 10:11.
Abstract
Regeneration is an evolutionarily conserved process in animal kingdoms, however, the regenerative capacities differ from species and organ/tissues. Mammals possess very limited regenerative potential to replace damaged organs, whereas non-mammalian species usually have impressive abilities to regenerate organs. The regeneration process requires proper spatiotemporal regulation from key signaling pathways. The canonical Notch and Wnt signaling pathways, two fundamental signals guiding animal development, have been demonstrated to play significant roles in the regeneration of vertebrates. In recent years, increasing evidence has implicated the cross-talking between Notch and Wnt signals during organ regeneration. In this review, we summarize the roles of Notch signaling and Wnt signaling during several representative organ regenerative events, emphasizing the functions and molecular bases of their interplay in these processes, shedding light on utilizing these two signaling pathways to enhance regeneration in mammals and design legitimate therapeutic strategies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping