PUBLICATION
The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus
- Authors
- Bhuiyan, M.S., Jiang, J.H., Kostoulias, X., Theegala, R., Lieschke, G.J., Peleg, A.Y.
- ID
- ZDB-PUB-210128-12
- Date
- 2021
- Source
- Antibiotics (Basel, Switzerland) 10(2): (Other)
- Registered Authors
- Bhuiyan, Saruar (Opu), Lieschke, Graham J.
- Keywords
- S. aureus, antimicrobial peptides, daptomycin, persistent infection
- MeSH Terms
- none
- PubMed
- 33498191 Full text @ Antibiotics (Basel)
Citation
Bhuiyan, M.S., Jiang, J.H., Kostoulias, X., Theegala, R., Lieschke, G.J., Peleg, A.Y. (2021) The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus. Antibiotics (Basel, Switzerland). 10(2).
Abstract
Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible S. aureus paired isolates using a zebrafish infection model. We showed that the control of DAP-R S. aureus infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R S. aureus and provide crucial insights into the adaptive evolution of this troublesome pathogen.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping