PUBLICATION

The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus

Authors
Bhuiyan, M.S., Jiang, J.H., Kostoulias, X., Theegala, R., Lieschke, G.J., Peleg, A.Y.
ID
ZDB-PUB-210128-12
Date
2021
Source
Antibiotics (Basel, Switzerland)   10(2): (Other)
Registered Authors
Bhuiyan, Saruar (Opu), Lieschke, Graham J.
Keywords
S. aureus, antimicrobial peptides, daptomycin, persistent infection
MeSH Terms
none
PubMed
33498191 Full text @ Antibiotics (Basel)
Abstract
Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible S. aureus paired isolates using a zebrafish infection model. We showed that the control of DAP-R S. aureus infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R S. aureus and provide crucial insights into the adaptive evolution of this troublesome pathogen.
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