|ZFIN ID: ZDB-PUB-201029-14|
Growth Performance After Agouti-Signaling Protein 1 (Asip1) Overexpression in Transgenic Zebrafish
Godino-Gimeno, A., Sánchez, E., Guillot, R., Rocha, A., Angotzi, A.R., Leal, E., Rotllant, J., Cerdá-Reverter, J.M.
|Source:||Zebrafish 17(6): 373-381 (Journal)|
|Registered Authors:||Cerdá-Reverter, José Miguel, Rotllant, Josep|
|Keywords:||growth, melanocortin, obesity, stress, transgenic, zebrafish|
|PubMed:||33112719 Full text @ Zebrafish|
Godino-Gimeno, A., Sánchez, E., Guillot, R., Rocha, A., Angotzi, A.R., Leal, E., Rotllant, J., Cerdá-Reverter, J.M. (2020) Growth Performance After Agouti-Signaling Protein 1 (Asip1) Overexpression in Transgenic Zebrafish. Zebrafish. 17(6):373-381.
ABSTRACTThe melanocortin system is a key structure in the regulation of energy balance. Overexpression of inverse agonists, agouti-signaling protein (ASIP), and agouti-related protein (AGRP) results in increased food intake, linear growth, and body weight. ASIP regulates dorsal-ventral pigment polarity through melanocortin 1 receptor (MC1R) and overexpression induces obesity in mice by binding to central MC4R. Asip1 overexpression in transgenic zebrafish (asip1-Tg) enhances growth, yet experiments show fish overexpressing Asip1 do not develop obesity even under severe feeding regimes. Asip1-Tg fish do not need to eat more to grow larger and faster; thus, increased food efficiency can be observed. In addition, asip1-Tg fish reared at high density are able to grow far more than wild-type (WT) fish reared at low density, although asip1-Tg fish seem to be more sensitive to crowding stress than WT fish, thus making the melanocortin system a target for sustainable aquaculture, especially as the U.S. Food and Drug Association has recently approved transgenic fish trading.