PUBLICATION
Marijuana and Opioid Use during Pregnancy: Using Zebrafish to Gain Understanding of Congenital Anomalies Caused by Drug Exposure during Development
- Authors
- Sarmah, S., Sales Cadena, M.R., Cadena, P.G., Marrs, J.A.
- ID
- ZDB-PUB-200814-2
- Date
- 2020
- Source
- Biomedicines 8(8): (Review)
- Registered Authors
- Marrs, James A.
- Keywords
- CBD, THC, birth defects, codeine, congenital anomalies, marijuana, morphine, opioid, zebrafish
- MeSH Terms
- none
- PubMed
- 32784457 Full text @ Biomedicines
Citation
Sarmah, S., Sales Cadena, M.R., Cadena, P.G., Marrs, J.A. (2020) Marijuana and Opioid Use during Pregnancy: Using Zebrafish to Gain Understanding of Congenital Anomalies Caused by Drug Exposure during Development. Biomedicines. 8(8):.
Abstract
Marijuana and opioid addictions have increased alarmingly in recent decades, especially in the United States, posing threats to society. When the drug user is a pregnant mother, there is a serious risk to the developing baby. Congenital anomalies are associated with prenatal exposure to marijuana and opioids. Here, we summarize the current data on the prevalence of marijuana and opioid use among the people of the United States, particularly pregnant mothers. We also summarize the current zebrafish studies used to model and understand the effects of these drug exposures during development and to understand the behavioral changes after exposure. Zebrafish experiments recapitulate the drug effects seen in human addicts and the birth defects seen in human babies prenatally exposed to marijuana and opioids. Zebrafish show great potential as an easy and inexpensive model for screening compounds for their ability to mitigate the drug effects, which could lead to new therapeutics.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping