PUBLICATION

Neural circuit reorganisation after spinal cord injury in zebrafish

Authors
El-Daher, F., Becker, C.G.
ID
ZDB-PUB-200701-22
Date
2020
Source
Current opinion in genetics & development   64: 44-51 (Review)
Registered Authors
Becker, Catherina G.
Keywords
none
MeSH Terms
  • Animals
  • Disease Models, Animal*
  • Neural Pathways/physiology*
  • Neurogenesis*
  • Recovery of Function*
  • Spinal Cord Injuries/physiopathology*
  • Spinal Cord Injuries/therapy*
  • Zebrafish
  • Zebrafish Proteins/metabolism*
PubMed
32604009 Full text @ Curr. Opin. Genet. Dev.
Abstract
Spinal cord injuries disrupt signalling from the brain leading to loss of limb, locomotion, sexual and bladder function, usually irreversible in humans. In zebrafish, recovery of function occurs in a few days for larvae or a few weeks for adults due to regrowth of axons and de novo neurogenesis. Together with its genetic amenability and optical clarity, this makes zebrafish a powerful animal model to study circuit reorganisation after spinal cord injuries. With the fast evolution of techniques, we can forecast significative improvements of our knowledge of the mechanisms leading to successful or failed recovery of spinal cord function. We review here the present knowledge on the subject, the new technological approaches and we propose future directions of research.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping