PUBLICATION
Neural circuit reorganisation after spinal cord injury in zebrafish
- Authors
- El-Daher, F., Becker, C.G.
- ID
- ZDB-PUB-200701-22
- Date
- 2020
- Source
- Current opinion in genetics & development 64: 44-51 (Review)
- Registered Authors
- Becker, Catherina G.
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Neural Pathways/physiology*
- Neurogenesis*
- Recovery of Function*
- Spinal Cord Injuries/physiopathology*
- Spinal Cord Injuries/therapy*
- Zebrafish
- Zebrafish Proteins/metabolism*
- PubMed
- 32604009 Full text @ Curr. Opin. Genet. Dev.
Citation
El-Daher, F., Becker, C.G. (2020) Neural circuit reorganisation after spinal cord injury in zebrafish. Current opinion in genetics & development. 64:44-51.
Abstract
Spinal cord injuries disrupt signalling from the brain leading to loss of limb, locomotion, sexual and bladder function, usually irreversible in humans. In zebrafish, recovery of function occurs in a few days for larvae or a few weeks for adults due to regrowth of axons and de novo neurogenesis. Together with its genetic amenability and optical clarity, this makes zebrafish a powerful animal model to study circuit reorganisation after spinal cord injuries. With the fast evolution of techniques, we can forecast significative improvements of our knowledge of the mechanisms leading to successful or failed recovery of spinal cord function. We review here the present knowledge on the subject, the new technological approaches and we propose future directions of research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping