PUBLICATION

Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish

Authors
Giacomini, A.C.V.V., Teixeira, K.H., Marcon, L., Scolari, N., Bueno, B.W., Genario, R., de Abreu, N.S., Demin, K.A., Galstyan, D.S., Kalueff, A.V., de Abreu, M.S.
ID
ZDB-PUB-200526-6
Date
2020
Source
Neuroscience letters   733: 135073 (Journal)
Registered Authors
Kalueff, Allan V.
Keywords
cognition, cortisol, light cycle, melatonin, zebrafish
MeSH Terms
  • Animals
  • Circadian Rhythm*
  • Cognition/drug effects*
  • Female
  • Hydrocortisone/blood*
  • Male
  • Melatonin/pharmacology*
  • Zebrafish
PubMed
32446774 Full text @ Neurosci. Lett.
Abstract
Melatonin is an important pineal hormone that regulates human and animal circadian rhythms and sleep. Mounting clinical and rodent evidence indicates that melatonin also modulates affective behaviors and cognition. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model organism in translational neuroscience research. Here, we evaluate the effects of 24-h melatonin treatment on behavior and physiology of adult zebrafish with circadian rhythm disturbed by a 24-h light exposure. While this light exposure evoked overt cognitive and neuroendocrine (cortisol) deficits in zebrafish, these effects were reversed by a 24-h melatonin treatment. Collectively, these findings suggest a positive modulation of affective and cognitive phenotypes in zebrafish by melatonin, and reinforce the growing utility of zebrafish models for studying circadian, cognitive and behavioral processes and their neuroendocrine regulation.
Genes / Markers
Figures
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Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping