ZFIN ID: ZDB-PUB-200403-177
BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin
Mateus, R., Holtzer, L., Seum, C., Hadjivasiliou, Z., Dubois, M., Jülicher, F., Gonzalez-Gaitan, M.
Date: 2020
Source: Cell Reports   30: 4292-4302.e7 (Journal)
Registered Authors: Mateus, Rita
Keywords: BMP, Smoc1, gradient, morphogen, organ growth, pectoral fin, scaling, theoretical physics, zebrafish
MeSH Terms:
  • Animal Fins/anatomy & histology
  • Animal Fins/growth & development
  • Animal Fins/metabolism*
  • Animal Fins/ultrastructure
  • Animals
  • Animals, Genetically Modified
  • Anisotropy
  • Bone Morphogenetic Proteins/metabolism*
  • Larva/ultrastructure
  • Organ Size
  • Phenotype
  • Signal Transduction*
  • Zebrafish/metabolism*
  • Zebrafish Proteins/metabolism
PubMed: 32209485 Full text @ Cell Rep.
Secreted growth factors can act as morphogens that form spatial concentration gradients in developing organs, thereby controlling growth and patterning. For some morphogens, adaptation of the gradients to tissue size allows morphological patterns to remain proportioned as the organs grow. In the zebrafish pectoral fin, we found that BMP signaling forms a two-dimensional gradient. The length of the gradient scales with tissue length and its amplitude increases with fin size according to a power-law. Gradient scaling and amplitude power-laws are signatures of growth control by time derivatives of morphogenetic signaling: cell division correlates with the fold change over time of the cellular signaling levels. We show that Smoc1 regulates BMP gradient scaling and growth in the fin. Smoc1 scales the gradient by means of a feedback loop: Smoc1 is a BMP agonist and BMP signaling represses Smoc1 expression. Our work uncovers a layer of morphogen regulation during vertebrate appendage development.