PUBLICATION
New function of zebrafish regulatory T cells in organ regeneration
- Authors
- Kikuchi, K.
- ID
- ZDB-PUB-191126-10
- Date
- 2019
- Source
- Current opinion in immunology 63: 7-13 (Review)
- Registered Authors
- Kikuchi, Kazu
- Keywords
- none
- MeSH Terms
-
- Animals
- Forkhead Transcription Factors/immunology
- Organogenesis/immunology*
- Regeneration/immunology*
- T-Lymphocytes, Regulatory/immunology*
- Zebrafish/immunology*
- Zebrafish/physiology*
- Zebrafish Proteins/immunology
- PubMed
- 31765917 Full text @ Curr. Opin. Immunol.
Citation
Kikuchi, K. (2019) New function of zebrafish regulatory T cells in organ regeneration. Current opinion in immunology. 63:7-13.
Abstract
Zebrafish can efficiently regenerate complex tissue structures with a highly developed innate and adaptive immune system, which provides a model to investigate the roles of immune cells in tissue repair and regeneration. Two groups recently reported zebrafish mutants deficient in a forkhead box P3 (FOXP3) ortholog, which helped reveal the conserved immunosuppressive function of zebrafish FOXP3 in vivo. Zebrafish FOXP3 defines the development of a subset of T cell lineage with the conserved gene expression profile of mammalian regulatory T cells (Tregs). In damaged organs, zebrafish Tregs rapidly migrate to the injury site, where they promote the proliferation of regeneration precursor cells by producing tissue-specific regenerative factors through a distinct mechanism from the canonical anti-inflammatory pathway. These findings illuminate the potential for using zebrafish as an effective model in Treg research and demonstrate organ-specific roles for Tregs in maintaining proregenerative capacity that could potentially be harnessed for use in diverse regeneration therapies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping