PUBLICATION

Tackling Acute Lymphoblastic Leukemia-One Fish at a Time

Authors
Sinha, A.A., Park, G., Frazer, J.K.
ID
ZDB-PUB-191117-2
Date
2019
Source
International Journal of Molecular Sciences   20(21): (Review)
Registered Authors
Frazer, Kimble
Keywords
B-ALL, MYC, T-ALL, leukemia, leukemia models, zebrafish
MeSH Terms
  • Animals
  • Humans
  • Neoplasms, Experimental*/genetics
  • Neoplasms, Experimental*/metabolism
  • Neoplasms, Experimental*/pathology
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/genetics
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/metabolism
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/pathology
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/genetics
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/metabolism
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/pathology
  • Zebrafish*/genetics
  • Zebrafish*/metabolism
PubMed
31731471 Full text @ Int. J. Mol. Sci.
Abstract
Despite advancements in the diagnosis and treatment of acute lymphoblastic leukemia (ALL), a need for improved strategies to decrease morbidity and improve cure rates in relapsed/refractory ALL still exists. Such approaches include the identification and implementation of novel targeted combination regimens, and more precise upfront patient risk stratification to guide therapy. New curative strategies rely on an understanding of the pathobiology that derives from systematically dissecting each cancer's genetic and molecular landscape. Zebrafish models provide a powerful system to simulate human diseases, including leukemias and ALL specifically. They are also an invaluable tool for genetic manipulation, in vivo studies, and drug discovery. Here, we highlight and summarize contributions made by several zebrafish T-ALL models and newer zebrafish B-ALL models in translating the underlying genetic and molecular mechanisms operative in ALL, and also highlight their potential utility for drug discovery. These models have laid the groundwork for increasing our understanding of the molecular basis of ALL to further translational and clinical research endeavors that seek to improve outcomes in this important cancer.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping