PUBLICATION
Toxicity effects in zebrafish embryos (Danio rerio) induced by prothioconazole
- Authors
- Tian, S., Teng, M., Meng, Z., Yan, S., Jia, M., Li, R., Liu, L., Yan, J., Zhou, Z., Zhu, W.
- ID
- ZDB-PUB-191002-7
- Date
- 2019
- Source
- Environmental pollution (Barking, Essex : 1987) 255: 113269 (Journal)
- Registered Authors
- Keywords
- Developmental toxicity, Metabolism disorders, Oxidative damage, Zebrafish embryos
- MeSH Terms
-
- Animals
- Aquatic Organisms
- Embryo, Nonmammalian/drug effects
- Embryo, Nonmammalian/physiology*
- Fungicides, Industrial/toxicity*
- Lipid Metabolism
- Lipid Peroxidation
- Triazoles/toxicity*
- Water Pollutants, Chemical/analysis
- Water Pollutants, Chemical/toxicity*
- Zebrafish/embryology
- Zebrafish/metabolism
- Zebrafish/physiology*
- PubMed
- 31574395 Full text @ Environ. Pollut.
- CTD
- 31574395
Citation
Tian, S., Teng, M., Meng, Z., Yan, S., Jia, M., Li, R., Liu, L., Yan, J., Zhou, Z., Zhu, W. (2019) Toxicity effects in zebrafish embryos (Danio rerio) induced by prothioconazole. Environmental pollution (Barking, Essex : 1987). 255:113269.
Abstract
Triazole fungicides are widely used in agriculture production and have adverse impacts on aquatic organisms. As one of the triazole fungicides, prothioconazole has been reported to cause many toxicological effects, but its risks to aquatic organisms are unknown. In this study, we systematically explored the toxicity effects of prothioconazole exposure on zebrafish embryos (Danio rerio) involving in developmental toxicity, oxidative damage and metabolism disorders. The results showed that prothioconazole exposure to zebrafish embryos produced a series of toxic symptoms, including hatching inhibition, shortening of body length, pericardial cyst and yolk cyst. In addition, prothioconazole exposure caused significant lipid peroxidation and oxidative damage. Particularly, we also found that metabolites and genes involved in lipid metabolism also showed significant changes. This study may provide theoretical basis for systematically assessing the potential risks of zebrafish embryos with prothioconazole exposure.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping