PUBLICATION
Regulation of spermatogonial development by Fsh: the complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis
- Authors
- Safian, D., Bogerd, J., Schulz, R.W.
- ID
- ZDB-PUB-190816-7
- Date
- 2019
- Source
- General and comparative endocrinology 284: 113244 (Journal)
- Registered Authors
- Bogerd, Jan, Schulz, Rüdiger W.
- Keywords
- Differentiation, Fsh, Igf signaling, Proliferation, Spermatogonia, Wnt signaling
- MeSH Terms
-
- Aging/metabolism*
- Animals
- Follicle Stimulating Hormone/metabolism*
- Male
- Somatomedins/metabolism*
- Spermatogonia/cytology
- Spermatogonia/growth & development*
- Testis/metabolism*
- Wnt Signaling Pathway*
- Zebrafish/metabolism*
- PubMed
- 31415728 Full text @ Gen. Comp. Endocrinol.
Citation
Safian, D., Bogerd, J., Schulz, R.W. (2019) Regulation of spermatogonial development by Fsh: the complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. General and comparative endocrinology. 284:113244.
Abstract
Spermatogenesis is a cellular developmental process characterized by the coordinated proliferation and differentiation activities of somatic and germ cells in order to produce a large number of spermatozoa, the cellular basis of male fertility. Somatic cells in the testis, such as Leydig, peritubular myoid and Sertoli cells, provide structural and metabolic support and contribute to the regulatory microenvironment required for proper germ cell survival and development. The pituitary follicle-stimulating hormone (Fsh) is a major endocrine regulator of vertebrate spermatogenesis, targeting somatic cell functions in the testes. In fish, Fsh regulates Leydig and Sertoli cell functions, such as sex steroid and growth factor production, processes that also control the development of spermatogonia, the germ cell stages at the basis of the spermatogenic process. Here, we summarize recent advances in our understanding of mechanisms used by Fsh to regulate the development of spermatogonia. This involves discussing the roles of insulin-like growth factor (Igf) 3 and canonical and non-canonical Wnt signaling pathways. We will also discuss how these locally active regulatory systems interact to maintain testis tissue homeostasis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping