PUBLICATION
Terpene Glycosides from Sanguisorba officinalis and Their Anti-Inflammatory Effects
- Authors
- Guo, D.L., Chen, J.F., Tan, L., Jin, M.Y., Ju, F., Cao, Z.X., Deng, F., Wang, L.N., Gu, Y.C., Deng, Y.
- ID
- ZDB-PUB-190814-9
- Date
- 2019
- Source
- Molecules 24(16): (Journal)
- Registered Authors
- Deng, Yun
- Keywords
- Sanguisorba officinalis, anti-inflammatory, structural elucidation, terpene glycosides, zebrafish
- MeSH Terms
-
- Animals
- Anti-Inflammatory Agents*/chemistry
- Anti-Inflammatory Agents*/isolation & purification
- Anti-Inflammatory Agents*/pharmacology
- Glycosides*/chemistry
- Glycosides*/isolation & purification
- Glycosides*/pharmacology
- Inflammation/drug therapy
- Inflammation/metabolism
- Inflammation/pathology
- Interleukin-6/metabolism
- Mice
- Nitric Oxide/metabolism
- RAW 264.7 Cells
- Sanguisorba/chemistry*
- Terpenes*/chemistry
- Terpenes*/isolation & purification
- Terpenes*/pharmacology
- Tumor Necrosis Factor-alpha/metabolism
- Zebrafish
- PubMed
- 31405117 Full text @ Molecules
Citation
Guo, D.L., Chen, J.F., Tan, L., Jin, M.Y., Ju, F., Cao, Z.X., Deng, F., Wang, L.N., Gu, Y.C., Deng, Y. (2019) Terpene Glycosides from Sanguisorba officinalis and Their Anti-Inflammatory Effects. Molecules. 24(16).
Abstract
Two new terpene glycosides (1-2) along with two known analogs (3-4) were obtained from the root of Sanguisorba officinalis, which is a common traditional Chinese medicine (TCM). Their structures were elucidated by nuclear magnetic resonance (NMR), electrospray ionization high resolution mass spectrometry (HRESIMS), and a hydrolysis reaction, as well as comparison of these data with the literature data. Compounds 1-4 exhibited anti-inflammatory properties in vitro by attenuating the production of inflammatory mediators, such as nitric oxide (NO) as well as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). An anti-inflammatory assay based on the zebrafish experimental platform indicated that compound 1 had good anti-inflammatory activity in vivo by not only regulating the distribution, but also by reducing the amount of the macrophages of the zebrafish exposed to copper sulfate.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping