PUBLICATION

Terpene Glycosides from Sanguisorba officinalis and Their Anti-Inflammatory Effects

Authors
Guo, D.L., Chen, J.F., Tan, L., Jin, M.Y., Ju, F., Cao, Z.X., Deng, F., Wang, L.N., Gu, Y.C., Deng, Y.
ID
ZDB-PUB-190814-9
Date
2019
Source
Molecules   24(16): (Journal)
Registered Authors
Deng, Yun
Keywords
Sanguisorba officinalis, anti-inflammatory, structural elucidation, terpene glycosides, zebrafish
MeSH Terms
  • Animals
  • Anti-Inflammatory Agents*/chemistry
  • Anti-Inflammatory Agents*/isolation & purification
  • Anti-Inflammatory Agents*/pharmacology
  • Glycosides*/chemistry
  • Glycosides*/isolation & purification
  • Glycosides*/pharmacology
  • Inflammation/drug therapy
  • Inflammation/metabolism
  • Inflammation/pathology
  • Interleukin-6/metabolism
  • Mice
  • Nitric Oxide/metabolism
  • RAW 264.7 Cells
  • Sanguisorba/chemistry*
  • Terpenes*/chemistry
  • Terpenes*/isolation & purification
  • Terpenes*/pharmacology
  • Tumor Necrosis Factor-alpha/metabolism
  • Zebrafish
PubMed
31405117 Full text @ Molecules
Abstract
Two new terpene glycosides (1-2) along with two known analogs (3-4) were obtained from the root of Sanguisorba officinalis, which is a common traditional Chinese medicine (TCM). Their structures were elucidated by nuclear magnetic resonance (NMR), electrospray ionization high resolution mass spectrometry (HRESIMS), and a hydrolysis reaction, as well as comparison of these data with the literature data. Compounds 1-4 exhibited anti-inflammatory properties in vitro by attenuating the production of inflammatory mediators, such as nitric oxide (NO) as well as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). An anti-inflammatory assay based on the zebrafish experimental platform indicated that compound 1 had good anti-inflammatory activity in vivo by not only regulating the distribution, but also by reducing the amount of the macrophages of the zebrafish exposed to copper sulfate.
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