PUBLICATION

A zebrafish tale of parabiosis, podocytes, and proteinuria

Authors
Chambers, B.E., Wingert, R.A.
ID
ZDB-PUB-190724-32
Date
2019
Source
Kidney International   96: 272-275 (Other)
Registered Authors
Chambers, Brooke, Wingert, Rebecca
Keywords
none
MeSH Terms
  • Animals
  • Kidney Glomerulus
  • Parabiosis
  • Podocytes*
  • Proteinuria
  • Zebrafish
PubMed
31331464 Full text @ Kidney Int.
Abstract
Glomerular damage is a harbinger of kidney dysfunction. Circulating permeability factors are implicated in causing primary and secondary damage to podocytes, leading to proteinuria and eventual progression to the nephrotic syndrome, but the mechanisms are not well understood. Müller-Deile et al. employed parabiosis with zebrafish embryos and found that a damaged glomerulus can impact a healthy one in a shared circulatory system. This methodology shows promise for elucidating kidney injury pathways in response to systemic disease.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping