PUBLICATION
Zebrafish and medaka as models for biomedical research of bone diseases
- Authors
- Lleras-Forero, L., Winkler, C., Schulte-Merker, S.
- ID
- ZDB-PUB-190724-15
- Date
- 2019
- Source
- Developmental Biology 457(2): 191-205 (Review)
- Registered Authors
- Schulte-Merker, Stefan, Winkler, Christoph
- Keywords
- none
- MeSH Terms
-
- Animals
- Biomedical Research
- Bone Diseases/genetics*
- Bone Diseases/physiopathology*
- Disease Models, Animal
- Genome/genetics
- Oryzias/genetics*
- Whole Genome Sequencing
- Zebrafish/genetics*
- PubMed
- 31325453 Full text @ Dev. Biol.
Citation
Lleras-Forero, L., Winkler, C., Schulte-Merker, S. (2019) Zebrafish and medaka as models for biomedical research of bone diseases. Developmental Biology. 457(2):191-205.
Abstract
The identification of disease-causing mutations has in recent years progressed immensely due to whole genome sequencing approaches using patient material. The task accordingly is shifting from gene identification to functional analysis of putative disease-causing genes, preferably in an in vivo setting which also allows testing of drug candidates or biotherapeutics in whole animal disease models. In this review, we highlight the advances made in the field of bone diseases using small laboratory fish, focusing on zebrafish and medaka. We particularly highlight those human conditions where teleost models are available.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping