ZFIN ID: ZDB-PUB-190712-7
Alginate oligosaccharide (AOS) improves immuno-metabolic systems by inhibiting STOML2 overexpression in high-fat-diet-induced obese zebrafish
Tran, V.C., Cho, S.Y., Kwon, J., Kim, D.
Date: 2019
Source: Food & function   10(8): 4636-4648 (Journal)
Registered Authors:
Keywords: none
MeSH Terms:
  • Alginates/administration & dosage*
  • Animals
  • Diet, High-Fat/adverse effects
  • Disease Models, Animal
  • Female
  • Humans
  • Lipid Metabolism/drug effects
  • Male
  • Obesity/drug therapy*
  • Obesity/etiology
  • Obesity/metabolism
  • Oligosaccharides/administration & dosage*
  • Zebrafish/genetics
  • Zebrafish/growth & development
  • Zebrafish/metabolism*
PubMed: 31290903 Full text @ Food Funct
This study aimed to evaluate the potentially beneficial effects of alginate oligosaccharide (AOS) on the modulation of immuno-metabolic pathways in high-fat-diet (HFD)-induced obese zebrafish and the underlying mechanism. AOS showed a marked anti-obesity effect in that it reduced body weight, BMI, and the blood glucose level. To understand the mechanisms of action of AOS, comparative proteomics was performed through UPLC-HDMSE analysis between HFD vs. normal diet (NFD) and HFD + AOS vs. HFD. Among 146 proteins differentially modulated by AOS in HFD-induced obesity zebrafish, STOML2 (Stomatin-like protein 2) was selected as a specific biomarker. AOS suppressed obesity and pathophysiological disorders in HFD-fed zebrafish by modulating lipid metabolism, suppressing inflammation, downregulating apoptosis-related genes, and improving immune function by inhibiting STOML2. Our results suggest that STOML2 can serve as a platform for further studies to discover novel treatments for metabolic disorders. AOS might be useful as a dietary health supplement, especially for reducing obesity.