PUBLICATION
Functional Integration of Newborn Neurons in the Zebrafish Optic Tectum
- Authors
- Boulanger-Weill, J., Sumbre, G.
- ID
- ZDB-PUB-190507-44
- Date
- 2019
- Source
- Frontiers in cell and developmental biology 7: 57 (Review)
- Registered Authors
- Sumbre, Germán
- Keywords
- activity-dependent development, neurogenesis, newborn neurons, optic tectum, visual system, zebrafish
- MeSH Terms
- none
- PubMed
- 31058148 Full text @ Front Cell Dev Biol
Citation
Boulanger-Weill, J., Sumbre, G. (2019) Functional Integration of Newborn Neurons in the Zebrafish Optic Tectum. Frontiers in cell and developmental biology. 7:57.
Abstract
Neurogenesis persists during adulthood in restricted parts of the vertebrate brain. In the optic tectum (OT) of the zebrafish larva, newborn neurons are continuously added and contribute to visual information processing. Recent studies have started to describe the functional development and fate of newborn neurons in the OT. Like the mammalian brain, newborn neurons in the OT require sensory inputs for their integration into local networks and survival. Recent findings suggest that the functional development of newborn neurons requires both activity-dependent and hard-wired mechanisms for proper circuit integration. Here, we review these findings and argue that the study of neurogenesis in non-mammalian species will help elucidate the general mechanisms of circuit assembly following neurogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping