| ZFIN ID: ZDB-PUB-190422-18 |
Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice and humans
Progatzky, F., Jha, A., Wane, M., Thwaites, R.S., Makris, S., Shattock, R.J., Johansson, C., Openshaw, P.J., Bugeon, L., Hansel, T.T., Dallman, M.J.
| Date: | 2019 |
|---|---|
| Source: | The Journal of allergy and clinical immunology 144(1): 342-345.e7 (Journal) |
| Registered Authors: | Bugeon, Laurence, Dallman, Maggie, Progatzky, Fränze |
| Keywords: | comparative cross-species analysis, mucosal innate immunity, nasal respiratory mucosa, resiquimod, vaccine adjuvants |
| MeSH Terms: |
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| PubMed: | 31002833 Full text @ J. Allergy Clin. Immunol. |
Citation
Progatzky, F., Jha, A., Wane, M., Thwaites, R.S., Makris, S., Shattock, R.J., Johansson, C., Openshaw, P.J., Bugeon, L., Hansel, T.T., Dallman, M.J. (2019) Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice and humans. The Journal of allergy and clinical immunology. 144(1):342-345.e7.
ABSTRACT
We compared live zebrafish, mouse and human nasal challenge responses to the TLR7/8 agonist resiquimod (R848). We found remarkably similar induction of mediators in the three species, offering novel mucosal models of innate anti-viral immunity.
ADDITIONAL INFORMATION
- Genes / Markers (5)
- Antibodies (1)
- Engineered Foreign Genes (2)
- Mutations and Transgenics (4)