ZFIN ID: ZDB-PUB-190422-18
Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice and humans
Progatzky, F., Jha, A., Wane, M., Thwaites, R.S., Makris, S., Shattock, R.J., Johansson, C., Openshaw, P.J., Bugeon, L., Hansel, T.T., Dallman, M.J.
Date: 2019
Source: The Journal of allergy and clinical immunology   144(1): 342-345.e7 (Journal)
Registered Authors: Bugeon, Laurence, Dallman, Maggie, Progatzky, Fränze
Keywords: comparative cross-species analysis, mucosal innate immunity, nasal respiratory mucosa, resiquimod, vaccine adjuvants
MeSH Terms:
  • Adult
  • Animals
  • Cytokines/immunology*
  • Female
  • Gills/drug effects
  • Gills/immunology
  • Humans
  • Imidazoles/pharmacology*
  • Immunity, Innate/drug effects
  • Immunity, Mucosal/drug effects
  • Male
  • Mice, Inbred C57BL
  • Middle Aged
  • Respiratory Mucosa/drug effects*
  • Respiratory Mucosa/immunology
  • Toll-Like Receptors/agonists*
  • Zebrafish
PubMed: 31002833 Full text @ J. Allergy Clin. Immunol.
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ABSTRACT
We compared live zebrafish, mouse and human nasal challenge responses to the TLR7/8 agonist resiquimod (R848). We found remarkably similar induction of mediators in the three species, offering novel mucosal models of innate anti-viral immunity.
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