ZFIN ID: ZDB-PUB-190406-16
Effect of propiconazole on the lipid metabolism of zebrafish embryos (Danio rerio)
Teng, M., Zhao, F., Zhou, Y., Yan, S., Tian, S., Yan, J., Meng, Z., Bi, S., Wang, C.
Date: 2019
Source: Journal of Agricultural and Food Chemistry   67(16): 4623-4631 (Journal)
Registered Authors:
Keywords: none
MeSH Terms:
  • Animals
  • Fatty Acid Synthases/genetics
  • Fatty Acid Synthases/metabolism
  • Female
  • Fungicides, Industrial/toxicity*
  • Lipid Metabolism/drug effects*
  • Lipoprotein Lipase/genetics
  • Lipoprotein Lipase/metabolism
  • Oxidative Stress/drug effects
  • Triazoles/toxicity*
  • Zebrafish/embryology*
  • Zebrafish/metabolism
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed: 30950260 Full text @ J. Agric. Food Chem.
Propiconazole is a triazole fungicide that has been widely used in agriculture and has been detected in the aquatic environment. This study aimed to investigate the effects of propiconazole exposure on lipid metabolism in the early life stages of zebrafish for 120 hours post-fertilization (hpf). Using the early life stages of zebrafish to address scientific questions is lower cost, more efficient and suitable for meeting current legislation than other traditional fish species. Exposure to propiconazole significantly inhibited the development of zebrafish embryos and larvae. This exposure also caused reduced locomotor activities in zebrafish. Furthermore, total cholesterol levels, lipoprotein lipase and fatty acid synthase activities were significantly decreased. The expression levels of genes involved in lipid metabolism were significantly up-regulated in response to propiconazole exposure. GC-MS/MS analysis revealed that fatty acids were significantly decreased. Together, the findings indicate the potential environmental risk of propiconazole exposure in the aquatic ecosystem.