PUBLICATION
Developing zebrafish disease models for in vivo small molecule screens
- Authors
- Lam, P.Y., Peterson, R.T.
- ID
- ZDB-PUB-190402-4
- Date
- 2019
- Source
- Current Opinion in Chemical Biology 50: 37-44 (Other)
- Registered Authors
- Lam, Pui Ying, Peterson, Randall
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Drug Evaluation, Preclinical
- High-Throughput Screening Assays/methods*
- Humans
- Mutagenesis
- Regeneration
- Wound Healing
- Zebrafish*/genetics
- PubMed
- 30928773 Full text @ Curr. Opin. Chem. Biol.
Citation
Lam, P.Y., Peterson, R.T. (2019) Developing zebrafish disease models for in vivo small molecule screens. Current Opinion in Chemical Biology. 50:37-44.
Abstract
The zebrafish is a model organism that allows in vivo studies to be performed at a scale usually restricted to in vitro studies. As such, the zebrafish is well suited to in vivo screens, in which thousands of small molecules are tested for their ability to modify disease phenotypes in zebrafish disease models. Numerous approaches have been developed for modeling human diseases in zebrafish, including mutagenesis, transgenesis, pharmacological approaches, wounding, and exposure to infectious or cancerous agents. We review the various strategies for modeling human diseases in zebrafish and discuss important considerations when developing zebrafish models for use in in vivo small molecule screens.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping