|ZFIN ID: ZDB-PUB-190308-4|
bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in the zebrafish
Ghersi, J.J., Mahony, C.B., Bertrand, J.Y.
|Source:||Development (Cambridge, England) 146(6): (Journal)|
|Registered Authors:||Bertrand, Julien, Ghersi, Joey, Mahony, Christopher|
|Keywords:||BMP signaling, Definitive hematopoiesis, Erythropoiesis, Hematopoietic Stem Cells, Zebrafish, Zinc finger proteins|
|PubMed:||30837221 Full text @ Development|
Ghersi, J.J., Mahony, C.B., Bertrand, J.Y. (2019) bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in the zebrafish. Development (Cambridge, England). 146(6):.
ABSTRACTHematopoiesis maintains the entire blood system and dysregulation of this process can lead to malignancies (leukemia), immunodeficiencies or red blood cell diseases (anemia, polycythemia vera). We took advantage of the zebrafish model that shares most of the genetic program involved in hematopoiesis with mammals to characterize a new gene of unknown function, si:ch73-299h12.2, expressed in the erythroid lineage during primitive, definitive and adult hematopoiesis. This gene, required during primitive and definitive erythropoiesis, encodes a C2H2 zinc finger protein that inhibits BMP signaling. We therefore named this gene: blood-inducing factor 1 and BMP inhibitory factor 1 (bif1). We identified a bif1 orthologue in Sinocyclocheilus Rhinocerous, another fish, and in the mouse genome. Both genes also inhibit BMP signaling when overexpressed in zebrafish. In conclusion, we deorphanized a new zebrafish gene of unknown function: bif1 codes for a zinc-finger protein that inhibits BMP signaling and also regulates primitive erythropoiesis and definitive hematopoiesis.