PUBLICATION
Opioid neurobiology, neurogenetics and neuropharmacology in zebrafish
- Authors
- Bao, W., Volgin, A.D., Alpyshov, E.T., Friend, A.J., Strekalova, T.V., de Abreu, M.S., Collins, C., Amstislavskaya, T.G., Demin, K.A., Kalueff, A.V.
- ID
- ZDB-PUB-190203-17
- Date
- 2019
- Source
- Neuroscience 404: 218-232 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- behavior, genetic models, opioids, pain, reward system, zebrafish
- MeSH Terms
-
- Analgesics, Opioid/metabolism
- Analgesics, Opioid/pharmacology*
- Analgesics, Opioid/therapeutic use
- Animals
- Disease Models, Animal*
- Humans
- Neurobiology
- Neuropharmacology
- Neurosciences
- Opioid-Related Disorders/genetics*
- Opioid-Related Disorders/metabolism
- Pain/drug therapy
- Pain/genetics
- Pain/metabolism
- Translational Research, Biomedical/methods*
- Translational Research, Biomedical/trends
- Zebrafish/genetics*
- Zebrafish/metabolism
- PubMed
- 30710667 Full text @ Neuroscience
Citation
Bao, W., Volgin, A.D., Alpyshov, E.T., Friend, A.J., Strekalova, T.V., de Abreu, M.S., Collins, C., Amstislavskaya, T.G., Demin, K.A., Kalueff, A.V. (2019) Opioid neurobiology, neurogenetics and neuropharmacology in zebrafish. Neuroscience. 404:218-232.
Abstract
Despite the high prevalence of medicinal use and abuse of opioids, their neurobiology and mechanisms of action are not fully understood. Experimental (animal) models are critical for improving our understanding of opioid effects in vivo. As zebrafish (Danio rerio) are increasingly utilized as a powerful model organism in neuroscience research, mounting evidence suggests these fish as a useful tool to study opioid neurobiology. Here, we discuss the zebrafish opioid system with the specific focus on opioid gene expression, the existing genetic models, as well as its pharmacological and developmental regulation. As many human brain diseases involve pain and aberrant reward, we also summarize zebrafish models relevant to opioid regulation of pain and addiction, including evidence of functional interplay between the opioid system and dopaminergic and other neurotransmitter mechanisms. Additionally, we critically evaluate the limitations of zebrafish models for translational opioid research and emphasize their developing utility for improving our understanding of evolutionarily conserved mechanisms of pain-related, addictive, affective and other behaviors, as well as for fostering CNS drug discovery.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping