PUBLICATION
The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: translational lessons from zebrafish
- Authors
- Genario, R., Giacomini, A.C.V.V., Demin, K.A., Dos Santos, B.E., Marchiori, N.I., Volgin, A.D., Bashirzade, A., Amstislavskaya, T.G., de Abreu, M.S., Kalueff, A.V.
- ID
- ZDB-PUB-190107-2
- Date
- 2019
- Source
- Neuroscience and biobehavioral reviews 99: 117-127 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- CNS, animal model, behavioral regulation, genetic model, melatonin
- MeSH Terms
-
- Animals
- Behavior, Animal/drug effects*
- Brain/drug effects*
- Brain/physiology
- Central Nervous System Diseases/drug therapy*
- Disease Models, Animal
- Humans
- Melatonin/pharmacology*
- Zebrafish/physiology
- PubMed
- 30611799 Full text @ Neurosci. Biobehav. Rev.
Citation
Genario, R., Giacomini, A.C.V.V., Demin, K.A., Dos Santos, B.E., Marchiori, N.I., Volgin, A.D., Bashirzade, A., Amstislavskaya, T.G., de Abreu, M.S., Kalueff, A.V. (2019) The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: translational lessons from zebrafish. Neuroscience and biobehavioral reviews. 99:117-127.
Abstract
Melatonin is an important hormone regulating circadian rhythm, neuroprotection and neuroimmune processes. However, its exact physiological roles in brain mechanisms remain poorly understood. Here, we summarize the mounting evidence implicating melatonin in brain disorders and behavior, based on clinical and experimental studies in-vivo. In addition to rodent models, the zebrafish (Danio rerio) is becoming increasingly utilized in biomedical and neuroscience research. Here, we discuss melatonin neurobiology of zebrafish, and parallel these findings with clinical and rodent data. We also discuss the genomic effects of melatonin in zebrafish, and emphasize the growing utility of zebrafish models to study melatonin neurobiology and drug discovery.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping