PUBLICATION

The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: translational lessons from zebrafish

Authors
Genario, R., Giacomini, A.C.V.V., Demin, K.A., Dos Santos, B.E., Marchiori, N.I., Volgin, A.D., Bashirzade, A., Amstislavskaya, T.G., de Abreu, M.S., Kalueff, A.V.
ID
ZDB-PUB-190107-2
Date
2019
Source
Neuroscience and biobehavioral reviews   99: 117-127 (Review)
Registered Authors
Kalueff, Allan V.
Keywords
CNS, animal model, behavioral regulation, genetic model, melatonin
MeSH Terms
  • Animals
  • Behavior, Animal/drug effects*
  • Brain/drug effects*
  • Brain/physiology
  • Central Nervous System Diseases/drug therapy*
  • Disease Models, Animal
  • Humans
  • Melatonin/pharmacology*
  • Zebrafish/physiology
PubMed
30611799 Full text @ Neurosci. Biobehav. Rev.
Abstract
Melatonin is an important hormone regulating circadian rhythm, neuroprotection and neuroimmune processes. However, its exact physiological roles in brain mechanisms remain poorly understood. Here, we summarize the mounting evidence implicating melatonin in brain disorders and behavior, based on clinical and experimental studies in-vivo. In addition to rodent models, the zebrafish (Danio rerio) is becoming increasingly utilized in biomedical and neuroscience research. Here, we discuss melatonin neurobiology of zebrafish, and parallel these findings with clinical and rodent data. We also discuss the genomic effects of melatonin in zebrafish, and emphasize the growing utility of zebrafish models to study melatonin neurobiology and drug discovery.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping