PUBLICATION
Deterministic fate assignment of Müller glia cells in the zebrafish retina suggest a clonal backbone during development
- Authors
- Rulands, S., Iglesias Gonzalez, A.B., Boije, H.
- ID
- ZDB-PUB-181109-9
- Date
- 2018
- Source
- The European journal of neuroscience 48(12): 3597-3605 (Journal)
- Registered Authors
- Keywords
- Danio rerio, GFAP, Retinal progenitor cell, bipolar cell, stochastic
- MeSH Terms
-
- Animals
- Animals, Genetically Modified/genetics
- Cell Differentiation/physiology
- Cell Proliferation/physiology
- Ependymoglial Cells/metabolism*
- Neurogenesis/physiology
- Neuroglia/metabolism*
- Neurons/metabolism
- Retina/metabolism*
- Stem Cells/metabolism*
- Zebrafish/metabolism
- Zebrafish Proteins/metabolism
- PubMed
- 30408243 Full text @ Eur. J. Neurosci.
Citation
Rulands, S., Iglesias Gonzalez, A.B., Boije, H. (2018) Deterministic fate assignment of Müller glia cells in the zebrafish retina suggest a clonal backbone during development. The European journal of neuroscience. 48(12):3597-3605.
Abstract
The optic cup houses multipotent retinal progenitor cells that proliferate and differentiate to form the mature retina, containing five main types of neurons and a single glial cell type, the Müller cell. Progenitors of the zebrafish optic cup generate clones that varies regarding the number and types of neurons, a process we previously showed could be described by stochastic models. Here, we present data indicating that each retinal progenitor cell, in the 24 hours post-fertilization optic cup, is predestined to form a single Müller cell. This striking fate assignment of Müller cells reveal a dual nature of retinal lineages where stochastic mechanisms produce variable numbers of neurons while there is a strong deterministic component governing the formation of glia cells. A possible mechanism for this stereotypic fate assignment could be the maintenance of a clonal backbone during retina development, which would be similar to invertebrate and rodent cortical neurogenesis. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping