PUBLICATION
Comparison of efficacy and toxicity of bevacizumab, endostar and apatinib in transgenic and human lung cancer xenograft zebrafish model
- Authors
- Jin, Y., Wei, L., Jiang, Q., Song, X., Teng, C., Fan, C., Lv, Y., Liu, Y., Shen, W., Li, L., Huang, D., Xin, T.
- ID
- ZDB-PUB-181028-4
- Date
- 2018
- Source
- Scientific Reports 8: 15837 (Journal)
- Registered Authors
- Li, Li
- Keywords
- none
- MeSH Terms
-
- A549 Cells
- Angiogenesis Inhibitors/pharmacology
- Angiogenesis Inhibitors/therapeutic use*
- Animals
- Antineoplastic Agents/pharmacology
- Antineoplastic Agents/therapeutic use
- Bevacizumab/pharmacology
- Bevacizumab/therapeutic use*
- Carcinoma, Non-Small-Cell Lung/drug therapy*
- Carcinoma, Non-Small-Cell Lung/metabolism
- Carcinoma, Non-Small-Cell Lung/pathology
- Disease Models, Animal
- Embryo, Nonmammalian/drug effects
- Embryo, Nonmammalian/metabolism
- Embryo, Nonmammalian/pathology
- Endostatins/pharmacology
- Endostatins/therapeutic use*
- Humans
- Larva/anatomy & histology
- Larva/drug effects
- Larva/metabolism
- Lung Neoplasms/drug therapy*
- Lung Neoplasms/metabolism
- Lung Neoplasms/pathology
- Pemetrexed/pharmacology
- Pemetrexed/therapeutic use
- Pyridines/pharmacology
- Pyridines/therapeutic use*
- Recombinant Proteins/pharmacology
- Recombinant Proteins/therapeutic use*
- Transplantation, Heterologous
- Xenograft Model Antitumor Assays
- Zebrafish/anatomy & histology
- Zebrafish/growth & development
- Zebrafish/metabolism
- PubMed
- 30367145 Full text @ Sci. Rep.
Citation
Jin, Y., Wei, L., Jiang, Q., Song, X., Teng, C., Fan, C., Lv, Y., Liu, Y., Shen, W., Li, L., Huang, D., Xin, T. (2018) Comparison of efficacy and toxicity of bevacizumab, endostar and apatinib in transgenic and human lung cancer xenograft zebrafish model. Scientific Reports. 8:15837.
Abstract
The poor prognosis in non-small-cell lung cancer has driven the development of novel targeted therapies. Vascular endothelial growth factor is the most potent force in mediating tumor angiogenesis, and many angiogenesis inhibitors have been developed for oncology treatment. We performed a study to characterize the efficacy, safety and tumor suppression of three lung cancer related anti-angiogenic drugs (bevacizumab, endostar and apatinib) using transgenic zebrafish embryo and human lung cancer xenotransplantation model. All three drugs demonstrated remarkable angiogenesis and tumor inhibition effect in the zebrafish model, within the nonlethal dose range. Endostar and bevacizumab showed competitive anti-tumor efficacy. The anti-tumor performance of apatinib was hamstrung by its elevated toxicity at 35 °C. The addition of pemetrexed to anti-angiogenesis therapy had no obvious additional benefit in tumors.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping