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ZFIN ID: ZDB-PUB-181020-20
Pulsed Electromagnetic Fields Increase Pigmentation through the p-ERK/p-p38 Pathway in Zebrafish (Danio rerio).
Kim, Y.M., Lim, H.M., Ro, H.S., Ki, G.E., Seo, Y.K.
Date: 2018
Source: International Journal of Molecular Sciences   19(10): (Journal)
Registered Authors:
Keywords: Danio rerio, electromagnetic field, melanogenesis, pigmentation, vitiligo, zebrafish
MeSH Terms:
  • Animals
  • Biological Assay
  • Electromagnetic Fields*
  • Embryo, Nonmammalian/metabolism
  • MAP Kinase Signaling System*
  • Melanins/metabolism
  • Phosphorylation
  • Pigmentation*
  • Zebrafish/embryology
  • Zebrafish/metabolism*
  • p38 Mitogen-Activated Protein Kinases/metabolism*
PubMed: 30336610 Full text @ Int. J. Mol. Sci.
Melanogenesis is a biological process resulting in the production of melanin pigment, which plays an important role in the prevention of sun-induced skin injury, and determines hair and skin color. So, a wide variety of approaches have been proposed to increase the synthesis of melanin. This study evaluated the effects of pulsed electromagnetic fields (PEMFs) on the pigmentation of zebrafish (Danio rerio) in vivo. We stimulated pigmentation in zebrafish by using specific frequencies and intensities of PEMFs. This study focuses on pigmentation using PEMFs, and finds that PEMFs, at an optimal intensity and frequency, upregulate pigmentation by the stimulated expression of tyrosinase-related protein 1 (TRP1), dopachrome tautomerase (DCT) through extracellular signal-regulated kinase(ERK) phosphorylation, and p38 phosphorylation signaling pathways in zebrafish. These results suggest that PEMFs, at an optimal intensity and frequency, are a useful tool in treating gray hair, with reduced melanin synthesis in the hair shaft or hypopigmentation-related skin disorders.