PUBLICATION
Goldfish: An old and new model system to study vertebrate development, evolution, and human disease
- Authors
- Omori, Y., Kon, T.
- ID
- ZDB-PUB-180917-4
- Date
- 2018
- Source
- Journal of biochemistry 165(3): 209-218 (Review)
- Registered Authors
- Omori, Yoshihiro
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease*/genetics
- Disease Models, Animal
- Goldfish/genetics
- Goldfish/growth & development
- Goldfish/physiology*
- Humans
- Models, Animal*
- Phenotype
- PubMed
- 30219851 Full text @ J. Biochem.
Citation
Omori, Y., Kon, T. (2018) Goldfish: An old and new model system to study vertebrate development, evolution, and human disease. Journal of biochemistry. 165(3):209-218.
Abstract
The goldfish (Carassius auratus) is a domesticated cyprinid teleost closely related to the crucian carp. Goldfish domestication occurred in South China around 1,000 years ago. At least 180 variants and 70 genetically established strains are currently produced. These strains possess diverse phenotypes in body shape, coloration, scales, and fin, eye, and hood morphology. These include biologically interesting phenotypes that have not been observed in mutants of zebrafish or medaka. In addition, goldfish strains have been maintained in a non-wild environment for several hundreds of generations, and certain goldfish strains have phenotypes similar to some human diseases. The recent progress in the assembly of the whole genome sequence of goldfish provides strong tools for a genetic analysis of these phenotypes. The whole genome duplication (WGD) event occurred in the goldfish genome 8-14 million years ago; this is one of the latest WGD in vertebrates. Goldfish are a useful model for studying genome evolution after the WGD event. This review focuses on the potential for goldfish as a model system in understanding the molecular basis of vertebrate development and evolution and human diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping