PUBLICATION
Zebrafish models of epigenetic regulation of CNS functions
- Authors
- Lakstygal, A.M., de Abreu, M.S., Kalueff, A.V.
- ID
- ZDB-PUB-180905-5
- Date
- 2018
- Source
- Brain research bulletin 142: 344-351 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- Behavior, DNA methylation, Epigenetics, Histone modification, Translational psychiatry, Zebrafish
- MeSH Terms
-
- Animals
- Central Nervous System/metabolism*
- Epigenesis, Genetic*
- Models, Animal
- Zebrafish*/genetics
- Zebrafish*/metabolism
- PubMed
- 30179679 Full text @ Brain Res. Bull.
Citation
Lakstygal, A.M., de Abreu, M.S., Kalueff, A.V. (2018) Zebrafish models of epigenetic regulation of CNS functions. Brain research bulletin. 142:344-351.
Abstract
Epigenetic regulation has become a key focus of neuroscience and biopsychiatry, implicating DNA methylation, histone modification and other epigenetic mechanisms in various CNS disorders. Animal (experimental) models are a useful tool for epigenetic studies. Although most such research has been performed in rodents, the zebrafish (Danio rerio) is rapidly emerging as a new promising model organism in neuroscience. These fish are particularly suitable for epigenetic studies due to their fully sequenced genome, easiness of genetic analyses and high physiological and genetic homology with humans. Here, we discuss mounting evidence of epigenetic regulation of CNS functions in zebrafish, and outline future directions of translational research in this field.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping