Zebrafish as a model for kidney function and disease
- Outtandy, P., Russell, C., Kleta, R., Bockenhauer, D.
- Pediatric nephrology (Berlin, Germany) 34(5): 751-762 (Review)
- Registered Authors
- Russell, Claire
- Acute kidney injury, Animal model, Chronic kidney disease, Kidney, Polycystic kidney disease, Renal diseases, Zebrafish
- MeSH Terms
- Disease Models, Animal*
- Glomerular Filtration Rate
- Kidney/anatomy & histology
- Kidney Diseases/etiology
- Kidney Diseases/physiopathology*
- Zebrafish/anatomy & histology
- 29502161 Full text @ Pediatr. Nephrol.
Outtandy, P., Russell, C., Kleta, R., Bockenhauer, D. (2018) Zebrafish as a model for kidney function and disease. Pediatric nephrology (Berlin, Germany). 34(5):751-762.
Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the various kidney diseases and to screen for therapeutic compounds, but the use especially of mammalian models should be minimised in the interest of animal welfare. Zebrafish are increasingly used, as they are genetically tractable and have a basic renal anatomy comparable to mammalian kidneys with glomerular filtration and tubular filtration processing. Here, we discuss how zebrafish have advanced the study of nephrology and the mechanisms underlying kidney disease.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes