ZFIN ID: ZDB-PUB-180223-57
Orientation-Selective Retinal Circuits in Vertebrates
Antinucci, P., Hindges, R.
Date: 2018
Source: Frontiers in neural circuits   12: 11 (Review)
Registered Authors: Antinucci, Paride, Hindges, Robert
Keywords: amacrine cell, cat, mouse, orientation selectivity, primate, rabbit, retinal ganglion cell, zebrafish
MeSH Terms:
  • Animals
  • Humans
  • Orientation/physiology*
  • Retina/cytology
  • Retina/physiology*
  • Visual Pathways/cytology
  • Visual Pathways/physiology
PubMed: 29467629 Full text @ Front. Neural Circuits
Visual information is already processed in the retina before it is transmitted to higher visual centers in the brain. This includes the extraction of salient features from visual scenes, such as motion directionality or contrast, through neurons belonging to distinct neural circuits. Some retinal neurons are tuned to the orientation of elongated visual stimuli. Such 'orientation-selective' neurons are present in the retinae of most, if not all, vertebrate species analyzed to date, with species-specific differences in frequency and degree of tuning. In some cases, orientation-selective neurons have very stereotyped functional and morphological properties suggesting that they represent distinct cell types. In this review, we describe the retinal cell types underlying orientation selectivity found in various vertebrate species, and highlight their commonalities and differences. In addition, we discuss recent studies that revealed the cellular, synaptic and circuit mechanisms at the basis of retinal orientation selectivity. Finally, we outline the significance of these findings in shaping our current understanding of how this fundamental neural computation is implemented in the visual systems of vertebrates.