PUBLICATION
Acaulide, an Osteogenic Macrodiolide from Acaulium sp. H-JQSF, an Isopod-Associated Fungus
- Authors
- Wang, T.T., Wei, Y.J., Ge, H.M., Jiao, R.H., Tan, R.X.
- ID
- ZDB-PUB-180130-9
- Date
- 2018
- Source
- Organic letters 20(4): 1007-1010 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Ascomycota*
- Isopoda
- Macrolides
- Molecular Structure
- PubMed
- 29376657 Full text @ Org. Lett.
Citation
Wang, T.T., Wei, Y.J., Ge, H.M., Jiao, R.H., Tan, R.X. (2018) Acaulide, an Osteogenic Macrodiolide from Acaulium sp. H-JQSF, an Isopod-Associated Fungus. Organic letters. 20(4):1007-1010.
Abstract
Acaulide (1), a macrodiolide with an unprecedented framework, was characterized along with its shunt products-acaulones A (2) and B (3)-from the culture of Acaulium sp. H-JQSF associated with the isopod Armadillidium vulgare. The spiro-linked 14-, 14-, and 6-membered cycles of 1 arise likely from iterative intermolecular Michael addition reactions. Biological evaluation in the prednisolone-induced osteoporotic zebrafish demonstrated that 1 is antiosteoporotic at 0.4 and 2.0 μM.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping