PUBLICATION
Clinical Consequences and Molecular Bases of Low Fibrinogen Levels
- Authors
- Neerman-Arbez, M., Casini, A.
- ID
- ZDB-PUB-180111-1
- Date
- 2018
- Source
- International Journal of Molecular Sciences 19(1): (Review)
- Registered Authors
- Neerman-Arbez, Marguerite
- Keywords
- bleeding, fibrinogen, genetics, thrombosis, women’s health, zebrafish
- MeSH Terms
-
- Afibrinogenemia/genetics
- Afibrinogenemia/metabolism
- Afibrinogenemia/pathology*
- Animals
- Disease Models, Animal
- Fibrinogen/chemistry
- Fibrinogen/genetics*
- Fibrinogen/metabolism
- Humans
- Phenotype
- PubMed
- 29316703 Full text @ Int. J. Mol. Sci.
Citation
Neerman-Arbez, M., Casini, A. (2018) Clinical Consequences and Molecular Bases of Low Fibrinogen Levels. International Journal of Molecular Sciences. 19(1).
Abstract
The study of inherited fibrinogen disorders, characterized by extensive allelic heterogeneity, allows the association of defined mutations with specific defects providing significant insight into the location of functionally important sites in fibrinogen and fibrin. Since the identification of the first causative mutation for congenital afibrinogenemia, studies have elucidated the underlying molecular pathophysiology of numerous causative mutations leading to fibrinogen deficiency, developed cell-based and animal models to study human fibrinogen disorders, and further explored the clinical consequences of absent, low, or dysfunctional fibrinogen. Since qualitative disorders are addressed by another review in this special issue, this review will focus on quantitative disorders and will discuss their diagnosis, clinical features, molecular bases, and introduce new models to study the phenotypic consequences of fibrinogen deficiency.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping